For the second straight Champions League campaign, Inter Milan and Real Madrid will meet in the group stages. The Spanish giants won both games against Inter in the 2020-21 season, but can they continue that fine record at the San Siro on Wednesday?

Inter Milan vs Real Madrid Odds

Inter Milan+150
Real Madrid+180
Total GoalsOdds
Over 2.5 Goals-128
Under 2.5 Goals+108

Inter Milan vs Real Madrid Preview

Real Madrid and Inter are the clear favorites to reach the next round of the Champions League in the soccer betting markets, but top spot could assure an easier passage throughout the knockout rounds. Both European giants should have no problem finishing in the top two spots, as Shakhtar Donetsk and Sheriff Tiraspol make up the other two teams in this group.

Many would have expected Inter to struggle this season after losing manager Antonio Conte in the summer, along with important first-team stars such as Romelu Lukaku and Achraf Hakimi. However, they have made a decent start to their Serie A title defense, claiming seven points from their first three games. They were held for the first time this season on Sunday, as Sampdoria claimed a 2-2 draw. Inter went ahead twice in that game, first through Federico Dimarco, and then Lautaro Martinez, but the hosts twice struck back.

Life back under Carlo Ancelotti has gone very well for Real Madrid to this point, as they have picked up ten points from a possible 12 available. The Spanish giants have picked up three wins and a draw. Real got their biggest win of the season to date on Sunday, as they beat Celta Vigo 5-2. Karim Benzema scored an incredible hat-trick in that win, with his final goal coming from the spot with three minutes remaining. Vinicius Jr also scored in the win, while there was also a debut goal for Eduardo Camavinga. 

Important Stats 

Real Madrid and Inter clashed in the group stages last season, with the Spanish side claiming wins in both fixtures. Their win at the San Siro was a 2-0 success. Inter’s poor record against Real stretches longer than just last season, as they have been beaten on four of the five previous occasions. 

However, Real have tended to struggle at the San Siro, as they have won just once in their previous nine trips to the famous stadium. Inter haven’t beaten Spanish opposition in the Champions League since a 3-1 win over Barcelona on their way to winning the competition in the 2009-10 season. 

Inter Milan vs Real Madrid Prediction

The odds are generous for whichever side you want to bet on in this fixture. However, given the dominance that Real have in this fixture, combined with the struggles that Inter have against Spanish opposition, the away win could be the most eye-catching selection. It is likely to be a close game, which means the over/under goals bet may be one to avoid, but an away win could be a good selection.

Pick: Real Madrid