Colorado Avalanche vs. Vegas Golden Knights NHL Picks: Western Conference Finals Game 2 Odds, Preview & Picks (May 22)

Published May 21, 4:52am ET by

Alex Dudley - Betting Preview Analyst and Sports Writer

Last updated May 21, 4:52am ET

Pick status
NHL Stanley Cup playoff action is set for May 22. Find the latest odds and our Colorado Avalanche vs. Vegas Golden Knights Game 2 picks here.

Credit: Shutterstock

Updated May 21, 4:52am ET

  • Vegas Golden Knights recorded a shock Game 1 success in Colorado on Wednesday
  • Pressure on the Avalanche to respond before the series moves to Nevada

The stakes increase in the NHL Playoffs this weekend, as Game 2 in the Western Conference Finals will see the Colorado Avalanche aiming to strike back against the Vegas Golden Knights.

Vegas were huge outsiders in Game 1, but they produced an excellent display to power to a 4-2 success. Another win on Friday would put the Golden Knights within touching distance of the Stanley Cup Finals.

Avalanche vs. Golden Knights Overview Watch On: ESPN+

DATE & TIME

Friday, May 22 2026 @ 8:00 PM ET
Avalanche
Ball Arena, Colorado
Golden Knights
GAME ODDS
BetOnline
Avalanche -180
Golden Knights +158

Pressure on the Avalanche to Bounce Back

For the first time this season, the Colorado Avalanche will have serious questions to answer. Jared Bednar’s side had little answer to the Vegas offense on Wednesday, leading to their first home defeat in this season’s postseason.

However, confidence can be gained from the fact that the Avalanche have bounced back impressively following setbacks this season. Gabriel Landeskog and Valeri Nichushkin scored the goals in the defeat in Game 1.

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Vegas Produce Season-Best Display When Required

The Vegas Golden Knights are an experienced outfit when it comes to games in the postseason. But, it could be argued that their 4-2 win on Wednesday was one of their best playoff displays in recent memory.

The Golden Knights scored twice in each of the second and third period, showing their efficiency to convert chances when they were created. Dylan Coghlan, Brett Howden, and Nic Dowd all scored goals. Ben Hutton and Brandon Saad both ended the night with assists.

Avalanche vs. Golden Knights Head-to-Head Record
TOTAL Avalanche Golden Knights DRAWS
Reguation WINS 53 26 27 -
GOALS 300 141 159

Colorado Avalanche vs. Vegas Golden Knights Picks

The Golden Knights flexed their muscles in Game 1, but there is likely to be a response by the Avalanche on Friday. Therefore, we expect Colorado to level the series ahead of the clash moving to the T-Mobile Arena next week.

Pick
Colorado Avalanche (-180)
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