Pistons vs Cavaliers Game 5 NBA Pick: Detroit Looks To Regain Series Lead (May 13)

Published May 12, 6:20am ET by

James Tillman - Betting Preview Analyst and Sports Writer

Last updated May 12, 6:20am ET

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Timberwolves-Spurs square off in G6

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Updated May 14, 6:51am ET

  • The Pistons look to seize control of the series after dropping Games 3 and 4 on the road.
  • Meanwhile, Cleveland held serve at home to even the score at 2-2.
  • These teams last met on May 11, with the Cavaliers claiming a 112-103 victory.

One of Wednesday’s NBA Playoff matchups features the Detroit Pistons hosting the Cleveland Cavaliers in Game 5 of this second-round series. Who has the edge in our Pistons vs Cavaliers pick?

Detroit Pistons vs. Cleveland Cavaliers Overview Watch On: ESPN

DATE & TIME

WEDNESDAY, MAY 13, 2026 @ 8:00 PM ET
Detroit Pistons
Little Caesars Arena
Detroit, MI
Cleveland Cavaliers
GAME ODDS
BetOnline
Detroit Pistons -4 (-110)
Cleveland Cavaliers +4 (-110)

The Pistons aim to bounce back at home

Detroit jumped out to a 2-0 lead, extending its postseason win streak to five games. Unfortunately, they have dropped their last two contests, including a 112-103 loss in Game 4.

ALSO SEE: Spurs vs Timberwolves | Odds and NBA Pick (May 12)

The Pistons were ahead 56-52 at the break, but then it happened. Cleveland responded with a 38-21 surge in the third quarter, which included a game-changing 24-0 run that spanned the last 12 seconds of the first half to the midway point of the third quarter.

Caris LeVert scored a team-high 24 points off the bench, converting 10 of his 16 shot attempts. Cade Cunningham chipped in with 19 points and six rebounds, while accounting for five of the team's 18 turnovers.

Cleveland's second-half surge keyed Game 4 win

The Cavaliers used a huge third-quarter burst to eventually pull away en route to leveling the series at two games apiece.

Donovan Mitchell put up 43 points, including 39 in the second half. He also collected five rebounds. James Harden finished with 24 points and 11 assists, going 5-of-9 from 3-point range.

Will the Pistons take care of business back in the Motor City, or will Cleveland win its third straight?

Pistons vs Cavaliers Game 5 NBA Pick

Detroit enters this contest as a four-point favorite. Here's a look at what you need to know for both teams ahead of Game 5.

  • The Pistons are 5-2 (SU) in their previous seven games.
  • Detroit is 4-2 ATS in its last six outings.
  • The Cavaliers are 13-7 (SU) in their previous 20 contests.
  • Cleveland is 3-6 ATS in its last nine matchups.

The Pistons are 5-15 in the previous 20 meetings in this series. Cleveland is 6-4 in its last 10 road games against Detroit. Home court has served both teams well thus far, and that trend will continue when these teams clash on Wednesday night.

Pick
Detroit Pistons
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