Buffalo Bills at San Francisco 49ers Preview

The Buffalo Bills square off with the San Francisco 49ers not in the Bay Area, but in Glendale, Arizona. For them, this is a very important event because of two things – the playoffs berth and the potential home advantage in the first round. Meanwhile. The 49ers are in desperate need of a win, which would allow them to stay in the race for the postseason. The surprising victory in the previous round against the LA Rams revived Kyle Shanahan’s team, who won’t receive another opportunity to chase the playoffs. However, they are heavily affected with the fact that they need to play away from home.

Bills at 49ers Odds

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Buffalo’s Western Tour

This is going to be the fourth straight contest for the Bills against one team from the west of the country. So far, they’ve posted two wins and a defeat, that lone one against the Cardinals on the road, via last-moment Hail Mary. In the other two, vs. the Chargers and the Seahawks, Josh Allen and his crew were more less confident without any troubles. Though, those two events were at home.

Allens and WR Stefon Diggs are among the best duos in the league, with the young QB posting 22 TDs so far with 8 picks. Of his 3028 yards, Diggs caught 80 receptions for 945 yards and four scores. 

The Bills are relying upon offense, as their defensive unit isn’t that great, allowing 387.8 yards from the scrimmage per game, which is 3.3 more than attack generates. What is a bit problematic for the guests in this one, is the running game, as they average 104.4 per contest. 

Unpredictable 49ers

For the second time this year, the 49ers defeated the Los Angeles Rams. Only now, they didn’t have Jimmy Garoppolo across the field. The guy who crushed the Rams in this one was Robbie Gould, hitting a 42-yard field goal as time ran out. After three consecutive losses, this was a breath of fresh air for Shanahan’s side.

The injury-shredded defense would contribute with one touchdown, as Javon Kinlaw returned the interception, while the other one came following Raheem Mostert’s 8-yard TD rush. Nick Mullens had his first game in the past five without a touchdown, but getting one of his passes picked. So far this year, the backup QB has six touchdowns and seven interceptions and isn’t brilliant at all.

We need to mention the defensive unit of the 49ers is doing its job pretty solid, allowing the rivals just 217.6 yards through the air, and if they disrupt Josh Allen, there might be some chance for a win.

Bills vs. 49ers Head to Head 

The Bills had the last laugh in this series, defeating the 49ers at home back in 2016 with 45-16. 


Believe it or not, the Bills are +1 point underdogs, and that is, from our point of view, a perfect chance to earn some easy money. Why? Well, because we think that a win against the Rams was just a lucky turn of events and that the Bills won’t allow that to repeat. Especially now, when they are aware that the 49ers could be dangerous. 

Plus, don’t forget that that San Francisco isn’t playing at home, but in Glendale at State Farm Stadium, due to COVID-19 restrictions.