Saints vs Cardinals NFL Pick: Will The Saints Emerge Victorious In Their Season Opener For The Seventh Straight Time? (Sep 7)

• The Saints are coming off a season in which they went 5-12.
• The Cardinals finished the 2024 campaign with an 8-9 record.
• These teams previously squared off on Oct. 20, 2022, with the Cardinals claiming a 42-34 victory.

One of the many games on Sunday’s NFL slate features the New Orleans Saints hosting the Arizona Cardinals. Who has the edge in our Saints vs Cardinals pick?

Saints Look To Bounce Back From Dismal 2024 Season

New Orleans won their first two games last season before dropping seven of their next nine contests. The team produced another two-game win streak before going 1-5 down the stretch.

The bad news is the Saints were tied for the second-worst record in the NFC at 5-12. The good news is they have won each of their last six season openers and look to continue that streak.

Arizona Aims To Contend For A Playoff Berth

Meanwhile, the Cardinals got off to a decent start last season, winning six of their first 10 games. Unfortunately, they went 2-5 down the stretch, missing the playoffs for the third consecutive season.

Arizona is considered a sleeper playoff team in some circles. Therefore, securing a win against an inferior opponent is crucial to getting their 2025 campaign off to a strong start.

Saints vs Cardinals NFL Pick

As many would expect. New Orleans enters this game as a 6.5-point underdog. Here are a few betting trends to consider for both teams ahead of this Week 1 matchup.

• The Saints are 6-0 straight-up (SU) in their last six season openers.
• New Orleans is 4-9 ATS in its previous 13 outings.
• The Cardinals are 4-16 in their last 20 road contests.
• Arizona is 8-3 ATS in its previous 11 matchups.

Despite the Cardinals’ road woes, the edge goes to them in this NFC matchup.