MLS: San Diego vs. San Jose Picks — Western Conference Leaders to Maintain Advantage? (Sep 27)

It has been a sensational season for San Diego, as they look on course to finish top of the Western Conference standings. But, will they be among the obvious San Diego vs. San Jose picks this weekend?

Despite being the newest franchise in the MLS, San Diego have taken the league by storm in 2025, winning 17 of their 31 matches and netting the second-highest tally of goals.

San Jose remain in playoff contention, as they sit two points adrift of the wild-card spots. However, they will be hoping to end a three-game losing sequence in California on Saturday.

San Diego vs. San Jose Overview

Odds

San Diego vs. San Jose Head-to-Head Record

A second competitive meeting between San Diego and San Jose is set for this weekend. San Diego recorded a 2-1 success on the road in the previous encounter in August.

San Diego Team News

The hosts will likely rotate their starting eleven after already securing their playoff spot in the Western Conference. Willy Kumado and Anibal Godoy could both be handed opportunities.

Possible Lineup

Dos Santos (GK); Bombino, McNair, Pilcher, Kumado; Valakari, De La Torre, Godoy; Dreyer, Mighten, Lozano

San Jose Team News

Despite dominating their previous fixture, San Jose were still 3-1 losers against St. Louis. A more clinical performance in front of goal will be expected on the road this Saturday.

Possible Lineup

Daniel (GK); Munie, Wilson, Romney; Costa, Vieira, Kaye, Espinoza; Arango, Judd, Bouda

San Diego vs. San Jose Picks

The hosts have been one of the most reliable teams in the MLS this season, and their attacking threat deserves huge respect this weekend. San Jose’s poor run of results is impacting their chances of finishing in a playoff spot in 2025, and a hammer-blow could be delivered on Saturday. A home win is among our standout San Diego vs. San Jose picks.