MLS: San Diego vs. Portland Picks — Western Conference Leaders to Extend Advantage (Aug 23)

The race to the finishing line in the MLS continues this weekend, as the Western Conference leaders bid to move eight points clear. Find our San Diego vs. Portland picks here.

San Diego have been the standout team in the West in 2025, winning 16 of their 27 matches, and losing a conference-low of just four matches. Last time out, they recorded an excellent 2-1 win on the road against San Jose.

The Portland Timbers remain in the playoff hunt, but they will need to improve their recent form after losing back-to-back matches against FC Dallas and FC Cincinnati.

San Diego vs. Portland Overview

Odds

San Diego vs. Portland Head-to-Head Record

This will only be the second meeting between San Diego and Portland. However, it will be the first time that they have clashed in a competitive fixture following Portland’s pre-season friendly win over their opponents in February.

San Diego Team News

The hosts have a near fully fit squad available for this showdown on Saturday. William Kumado is the only first-team player missing due to injury.

Possible Lineup

C. dos Santos (GK); L. Bombino, C. McVey, M. Duah, A. Harangi, O. Valakari, J. Tverskov, A. Godoy, T. Angel, A. Dreyer, D. Vazquez

Portland Team News

Jonathan Rodriguez remains a long-term issue for the Timbers, as the forward remains out with a hip injury.

Possible Lineup

M. Crepeau (GK); J. Fory, D. Zuparic, F. Surman, Antony, J. Mosquera, D. da Costa, F. Mora, C. Paredes, O. Fernandez, K. Kelsy

San Diego vs. Portland Picks

Despite a pre-season loss against Portland, it’s hard to overlook the hosts when making San Diego vs. Portland picks this weekend.

San Diego have been the dominant team in the Western Conference, and they have been excellent in the offensive areas throughout the campaign. A routine victory could be recorded on Saturday.