Premier League Matchday 6 Picks & Preview (Sep 27-29)
This action in the English top-flight continues to come thick and fast. All eyes will be on a huge clash...
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Published Sep 25, 3:14am ET by Alex Dudley
Credit: Shutterstock
Last updated Sep 25, 3:14am ET
This action in the English top-flight continues to come thick and fast. All eyes will be on a huge clash at St. James’ Park on Sunday, as Arsenal bid to get their title challenge back on track against Newcastle. You can find our Premier League picks for matchday 6 here.
Premier League Matchday 6 Schedule
| Stat | Information |
|---|---|
| When | Saturday, September 27, 2025 – Monday, September 29, 2025 |
| Where | Various Stadiums, England |
| How to Watch | NBC/Peacock |
Premier League Matchday 6 Picks
Brentford vs. Man United
The EPL weekend kicks off at the Gtech Community Stadium, as Man United chase successive victories for the first time in two seasons.
However, Brentford have won two of their last three league fixtures against the Red Devils. Despite that, United’s performances have been better this term than they were last, and they could end a poor run on the road this weekend after going seven without a victory.
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Pick
Man United (+105)
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Crystal Palace vs. Liverpool
Two unbeaten teams in the Premier League this season lock horns at Selhurst Park on Saturday.
Liverpool are chasing six straight wins to start the new season, while Crystal Palace have enjoyed their best start to a campaign since 1990-91. However, the head-to-head record could point to the most logical angle. Liverpool have won nine of their last ten away matches against the Eagles.
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Pick
Liverpool (-106)
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Man City vs. Burnley
Burnley have enjoyed a respectable start to the new season, but they have failed to win in their last 19 away matches against Man City.
City have won 22 of their last 24 fixtures against newly promoted sides, and they have claimed victories in each of their last 13 fixtures with the Clarets. Across that period, they have scored 46 goals.
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Pick
Man City (-575)
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Chelsea vs. Brighton
Brighton have a positive recent record against Chelsea, winning three of the last six league meetings.
However, their defensive record is a notable concern ahead of this fixture, as they have kept just one clean sheet in their last 17 matches. Chelsea’s underwhelming start to the season has created negative headlines, and their passive nature could ensure that there is value in the draw on Saturday.
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Pick
The Draw (+300)
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Leeds vs. Bournemouth
Leeds scored their opening goals from open play in a 3-1 win last weekend, and they have already excelled at Elland Road in 2025-26.
Bournemouth have made their best start to a Premier League campaign, winning three of their opening five. However, a home win could be an interesting angle on Saturday, as the Whites have won all seven of their league matches against the Cherries.
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Pick
Leeds (+208)
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Nottingham Forest vs. Sunderland
Sunderland have enjoyed an excellent start to the new season, picking up eight points from their opening five matches.
Forest are yet to hit the heights of last season, and they have lost four of their last six at the City Ground. It could be worth noting that Sunderland have won five of their last seven league matches against the Tricky Trees. A chance could be taken on an away win.
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Pick
Sunderland (+360)
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Tottenham vs. Wolves
Life under Thomas Frank has got off to an excellent start at Tottenham, and they have already accumulated ten points in their opening five matches. Wolves have suffered defeats in each of their opening five fixtures, and they are the only team in the EPL yet to pick up a single point.
Despite having a poor record against this weekend’s opponents, the preference is for a Tottenham win when making Premier League picks.
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Pick
Tottenham (-207)
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Aston Villa vs. Fulham
Aston Villa’s patchy start to the season sees them sit in the bottom three places in the EPL standings. However, they have an excellent record against Fulham after winning seven of the last eight head-to-head meetings. Fulham have won just one of their last 21 trips to Villa Park. Based on the trends, the preference is for the home win on Sunday.
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Pick
Aston Villa (+133)
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Newcastle vs. Arsenal
Newcastle have recorded wins in each of their last three home matches against Arsenal. However, the Gunners have suffered defeats in just one of their last 16 on the road. Both sides have struggled for creativity so far this season, and that will be a concern this weekend. Therefore, a chance could be taken on the points being shared.
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Pick
The Draw (+246)
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Everton vs. West Ham
The pressure continues to mount on Graham Potter, as West Ham sit 19th in the standings after defeats in their last two. Everton suffered a second loss of the season in their latest outing, but they should be capable of getting their form back on track back in front of their home fans on Monday evening.
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Pick
Everton (-124)
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