Last updated Sep 25, 4:31am ET

It has been a patchy period of form for one of the hot favorites to win the Liga MX title this season. However, they will be aiming to get back to winning ways on Sep 27. You can find our Monterrey vs. Santos Laguna picks here.

Monterrey comes into this round sitting third in the Liga MX standings after failing to win in each of their last two. A return to form will be expected following a shock defeat in midweek.

Santos Laguna’s confidence should be high after a victory in their latest fixture in the Mexican top-flight. That success ended a four-game winless sequence in Liga MX.

Monterrey vs. Santos Laguna Overview

StatInformation
Date & TimeSaturday, September 27, 2025 @ 9:00 PM ET
WhereEstadio BBVA, Mexico
How to WatchTUDN

Odds

Match ResultOdds
Monterrey-320
Draw+490
Santos Laguna+750

Monterrey vs. Santos Laguna Head-to-Head Record

TotalMonterreySantos LagunaDraws
Wins66251922
Liga MX Games55211519
Goals18710582 

Monterrey have recorded victories in each of the last five head-to-head meetings between these sides. Their latest success was a 4-2 victory in March.

Monterrey Team News

It’s likely that the hosts will make a couple of changes to their starting eleven this weekend following 6-2 defeat against Toluca in midweek. Anthony Martial could be in line for a start.

Possible Lineup

Mele (GK); Ramos, Chavez, Reyes; Aguirre, Guzman, Oliver, Arteaga; Corona, Canales; Martial

Santos Laguna Team News

Bruno Barticciotto will be suspended this weekend after being sent off in Santos Laguna’s 1-0 victory against Club Tijuana in midweek.

Possible Lineup

Lopez (GK); Abella, Sanchez, Balanta, Amione; Mariscal, Guemez; Sordo, Carrillo, Palacios; Ocejo

Monterrey vs. Santos Laguna Picks

Monterrey will be aiming to put their midweek hammering behind them quickly on Saturday. Their dominant historical record against this weekend’s opponents deserves huge respect, and we could see a comprehensive showing on their return to action. Therefore, the preference is for a home win when making Monterrey vs. Santos Laguna picks.

Pick
Monterrey (-320)
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Alex Dudley
Alex Dudley

Sports Analyst and Betting Expert

Alex has over 15 years of experience in sports betting, specializing in soccer and horse racing. He uses his deep knowledge of markets and strategies to guide readers through disciplined and informed betting.

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