Another high-quality weekend of Spanish top-flight action is set for between September 19 and 21, with Real Madrid and Barcelona both out to showcase their championship credentials. You can find our La Liga picks for matchday five here.

La Liga Matchday 5 Schedule

StatInformation
WhenFriday, September 19, 2025 – Sunday, September 21, 2025
WhereVarious Stadiums, Spain
How to WatchESPN

La Liga Matchday 5 Picks

Betis vs. Real Sociedad

Real Sociedad have made a slow start to the new La Liga season, having failed to win in their opening four. Betis haven’t fared much better over the last two seasons, winning one of their last nine. Despite that, draws have been a common outcome over that period, with six of their clashes ending in ties. Based on the form of both sides, that could be an interesting angle on Friday.

Pick
The Draw (+244)
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Girona vs. Levante

Girona have failed to win in their opening four matches this season, marking their worst ever start to a top-flight season. Levante have also failed to win so far this term, and they have conceded at least twice in every match this term. Both sides need a positive result this weekend, but it could be an excellent opportunity for the hosts.

Pick
Girona (-108)
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Real Madrid vs. Espanyol

Two sides that have made excellent starts to the new season collide on Saturday. Real Madrid won their opening four matches this term for the 14th time in their history. Meanwhile, Espanyol have avoided defeat in their last five matches, winning on four occasions. However, Los Blancos have won 24 of their last 27 home fixtures against Espanyol.

Pick
Real Madrid (-465)
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Alaves vs. Sevilla

Alaves have avoided defeat in their last six against Sevilla in La Liga. Meanwhile, they have been in excellent recent form after going six without defeat in home matches. The trends point to a home victory this weekend, especially considering that Sevilla’s consistency has been an issue throughout 2025.

Pick
Alaves (+142)
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Villarreal vs. Osasuna

Villarreal have quickly become one of the best home teams in Spain, having avoided defeat in each of their last six. Osasuna also rarely lose in La Liga after being beaten in just two of their last eight. However, the head-to-head trends point to a win for the hosts, as Villarreal have avoided defeat in their last six against Osasuna.

Pick
Villarreal (-185)
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Valencia vs. Athletic Bilbao

Valencia have suffered defeats in their last two against Bilbao, while the visitors have won three of their last six at the Mestalla. Bilbao were beaten in their latest outing, but they haven’t suffered successive defeats in May 2023. Valencia’s form was knocked following a 6-0 loss against Barcelona last weekend. An away victory looks among the standout La Liga picks.

Pick
Athletic Bilbao (+150)
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Rayo Vallecano vs. Celta Vigo

Vallecano have failed to win in their last three La Liga matches, but they have avoided defeat in their last five at home. Celta Vigo have played out draws in their last four league fixtures. However, a home victory looks hard to overlook based on the fact that Vallecano have avoided defeat in their last 14 against Celta at Estadio de Vallecas.

Pick
Rayo Vallecano (+132)
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Mallorca vs. Atletico Madrid

Mallorca have a pleasing record against Atletico in home matches, winning six of their last eleven. However, Atletico have recorded wins in their last five against their opponents this weekend. Mallorca’s form would be a concern after failing to gain a victory in their last seven. Therefore, the smart money will be on the away win.

Pick
Atletico Madrid (-133)
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Elche vs. Oviedo

Elche boast a positive record against their opponents this weekend, winning three of their last six. Meanwhile, they come into this round of matches having suffered just one defeat in their last nine at home against Oviedo. It appears very hard to overlook the prospect of a home victory on Sunday.

Pick
Elche (+101)
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Barcelona vs. Getafe

Barcelona look impossible to bet against this weekend. The Spanish giants have avoided defeat in their 20 home matches against Getafe, and they have netted at least once in each of their 24 matches in La Liga. Getafe will take confidence from their start to the season after accumulating nine points, but that could count for very little on Sunday.

Pick
Barcelona (-420)
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Alex Dudley
Alex Dudley

Sports Analyst and Betting Expert

Alex has over 15 years of experience in sports betting, specializing in soccer and horse racing. He uses his deep knowledge of markets and strategies to guide readers through disciplined and informed betting.

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