Last updated Sep 12, 4:55am ET

A busy weekend of action in Spain’s top flight is set for this weekend, with Real Madrid and Barcelona both set to take to the field. You can find our La Liga picks for matchday four here.

La Liga Matchday 4 Schedule

StatInformation
WhenFriday, September 12, 2025 – Monday, September 15, 2025
WhereVarious Stadiums, Spain
How to WatchESPN

La Liga Matchday 4 Picks

Sevilla vs. Elche

Elche bid to maintain their unbeaten start to the new season on Friday, and they could go four without loss for the second time in their top-flight history. Sevilla have avoided defeat in their last 21 league home matches against Elche, which is a worrying trend. A home win could be preferred based on the trends.

Pick
Sevilla (-117)
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Getafe vs. Oviedo

Getafe’s poor home record stretches back to last season, as they have now lost each of their last five at Coliseum. Oviedo recorded a win in their last fixture in the league, and they looked more assured at both ends of the field. That could continue into this weekend, and a win on the road could be an interesting angle.

Pick
Oviedo (+375)
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Real Sociedad vs. Real Madrid

Real Madrid bid to extend their advantage at the La Liga summit on Saturday. They have won each of their last six, and kept clean sheets in four of their last five. An away win looks challenging to oppose based on the trends, as they have won four of their last five against Sociedad.

Pick
Real Madrid (-160)
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Athletic Bilbao vs. Alaves

Bilbao have recorded victories in four of their last six against Alaves. The visitors this weekend have failed to score in their last five trips to San Mames. It doesn’t aid their chances that they have lost two of their last three on the road. A home win looks like the most likely outcome when making La Liga picks.

Pick
Atletic Bilbao (-165)
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Atletico Madrid vs. Villarreal

Atletico Madrid have avoided defeat in their last five matches against Villarreal, but three fixtures over that period have ended in draws. Villarreal have also taken points from eight of their last eleven on the road against Atletico. Based on their underwhelming start to the season, there could be value in the draw this weekend.

Pick
The Draw (+262)
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Celta Vigo vs. Girona

Girona have recorded wins in just one of their last six away matches against Celta Vigo. Celta have been draw specialists in La Liga so far this season, playing out ties in their last three. Girona’s poor start to the season could give the hosts the perfect opportunity to finally get a win on the board.

Pick
Celta Vigo (-144)
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Levante vs. Betis

Levante have started the season in extremely poor form, losing each of their opening three matches for just the second time in their history. Betis have been strong on the road across the last two seasons, scoring at least once in each of their last eleven away matches. Preference is for the away victory this weekend.

Pick
Betis (+120)
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Osasuna vs. Rayo Vallecano

Osasuna have failed to win in their last three matches against Vallecano. However, there is a strong chance that could change this weekend. The hosts have won each of their last five home matches, and have excelled defensively, keeping four clean sheets.

Pick
Osasuna (+152)
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Barcelona vs. Valencia

Barcelona have avoided defeat in their last ten matches against Valencia, winning on eight occasions across that period. However, since January, Valencia have picked up points in eight of their last eleven fixtures on the road. It is hard to foresee that trend being maintained on Sunday, and a home win is the most likely outcome.

Pick
Barcelona (-440)
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Espanyol vs. Mallorca

Espanyol have enjoyed a reliable start to the new season, picking up seven points from their opening three matches. Their head-to-head record against Mallorca bodes well for their chances this weekend, as they have won their last six against their opponents on Monday at RCDE Stadium.

Pick
Espanyol (+127)
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Alex Dudley
Alex Dudley

Sports Analyst and Betting Expert

Alex has over 15 years of experience in sports betting, specializing in soccer and horse racing. He uses his deep knowledge of markets and strategies to guide readers through disciplined and informed betting.

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