Another fascinating round of La Liga matches are set for this weekend, as the major contenders for the Spanish top-flight title are all in action. You can find our La Liga picks for every clash on matchday two here.

La Liga Matchday 2 Schedule

StatInformation
WhenFriday, August 22, 2025 – Monday, August 25, 2025
WhereVarious Stadiums, Spain
How to WatchESPN

La Liga Matchday 2 Picks

Betis vs. Alaves

Real Betis endured a frustrating start to the new season after being held to a 1-1 draw on the opening day by Elche. Meanwhile, Alaves made a winning start to the campaign with a dominant showing against Levante. A shock result could be on the cards this weekend, as Alaves are unbeaten in their last five competitive matches against Betis, and something seems amiss with the hosts.

Pick
Alaves (+355)
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Mallorca vs. Celta Vigo

Mallorca were firmly put in their place on the opening day after suffering a 3-0 home loss against Barcelona. However, the hosts did see Manu Morlanes and Vedat Muriqi sent off in the defeat. Celta Vigo didn’t fare much better on the opening day after suffering a 2-0 loss against Getafe. But, they did carry a goal threat, which makes them our selection this weekend.

Pick
Getafe (+160)
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Atletico Madrid vs. Elche

Atletico Madrid have already lost ground in the race for the La Liga title following a defeat on matchday one against Espanyol. Elche battled to an excellent home draw against Betis in their opening fixture. However, with home advantage, Atletico should be very difficult to beat in Spain this weekend.

Pick
Atletico Madrid (-415)
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Levante vs. Barcelona

Barcelona produced a clinical attacking display on matchday one, claiming a 3-0 success against Mallorca. Levante have already looked defensively weak this term following a poor defeat against Alaves last weekend. Based on their strong attacking record, Barcelona look good value to record a second straight win.

Pick
Barcelona (-380)
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Osasuna vs. Valencia

Valencia could be among the leading European contenders this season, and they lost little in claiming a draw on the opening day against Real Sociedad. Osasuna also produced a reliable enough performance in their opener after just falling to a 1-0 defeat against Real Madrid. A tight encounter is expected, but a draw could rank among the prominent La Liga picks.

Pick
The Draw (+215)
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Real Sociedad vs. Espanyol

Real Sociedad were held to a draw on the opening day of the new season by Valencia, but they could be challenging to oppose in their first home match of the new season. Sociedad boasts an excellent record against their opponents, winning each of the last five head-to-head encounters.

Pick
Real Sociedad (-121)
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Villarreal vs. Girona

Girona endured a miserable start to the new season after falling to defeat at home against Rayo Vallecano. Villarreal had no such issues after claiming a straightforward win over Oviedo. The hosts could be the team to beat this weekend, as they bid to maintain their 100% record.

Pick
Villarreal (-185)
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Oviedo vs. Real Madrid

Oviedo will be huge outsiders in their first home match of the new season, and they were beaten on their return to La Liga against Villarreal last weekend. Real Madrid were workman-like in their opener, with Kylian Mbappe netting the winner against Osasuna. A more assured performance is expected from the visitors this Sunday.

Pick
Real Madrid (-320)
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Athletic Bilbao vs. Vallecano

Athletic Bilbao will be a dark horse contender for a European spot this term, and they made an excellent start to the campaign after overcoming Sevilla on matchday one. Their dominant home advantage deserves attention this week, and we fully expect Bilbao to maintain their 100% record.

Pick
Athletic Bilbao (-140)
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Sevilla vs. Getafe

Sevilla were edged out on MD1 by Bilbao, but they showed plenty to suggest that an improved campaign is likely this term. Getafe also showed their quality on the opening weekend after recording a 2-0 win over Celta Vigo. However, home advantage could count for a lot when making La Liga picks this Sunday.

Pick
Sevilla (+127)
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Alex Dudley
Alex Dudley

Sports Analyst and Betting Expert

Alex has over 15 years of experience in sports betting, specializing in soccer and horse racing. He uses his deep knowledge of markets and strategies to guide readers through disciplined and informed betting.

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