Texans vs Colts NFL Pick: Houston Visits Indy 2 Games Back in the AFC South (Nov 30)

Published Nov 28, 11:38am ET by

Paul Lebowitz - Betting Preview Analyst and Sports Writer

Last updated Nov 28, 11:38am ET

Pick status

Grok AI

  • For NFL Week 13, the Texans (6-5) travel to play the Colts (8-3) in a meeting of AFC South rivals
  • Houston has won 3 straight and rebounded following an 0-3 start to get into playoff contention
  • Indianapolis is coming off a loss to the Chiefs, and QB Daniel Jones is dealing with a fractured fibula, but insists he will play
  • Houston won both matchups with Indy in 2024 on their way to the division title
Indianapolis Colts vs. Houston Texans Overview Watch On: CBS

DATE & TIME

Sunday, November 30, 2025 @ 1:00 PM ET
Indianapolis Colts
Lucas Oil Stadium
Indianapolis, IN
Houston Texans
GAME ODDS
BetOnline
Indianapolis Colts -3.5 (-115)
Houston Texans +3.5 (-105)

The Next 6 Weeks Will Determine Houston's Season

The Texans were in trouble after three weeks, having lost to the Rams, Buccaneers, and Jaguars. Since then, they have gone 6-2. Admittedly, two of the wins were over the atrocious Titans. But they also beat the Ravens and Bills. Given their hard-hitting defense, they are a threat in the playoffs, if they get there.

Starting QB C.J. Stroud has not played since Week 9 with a concussion. He has returned to practice and is expected to play against the Colts.

Davis Mills has played well in his stead with an 83.7 passer rating, 5 TDs, and 1 interception.

As expected, Houston's defense is one of the NFL's best. They are 2nd in fewest points allowed per game, 3rd in defensive passing yards per game, and 5th in defensive rushing yards per game. They are +10 in takeaway differential. As a team, they have 33 sacks led by Danielle Hunter (11 sacks) and Will Anderson (10.5 sacks).

ALSO SEE: Jaguars vs Titans | Week 13 Odds & NFL Pick (Nov 30)

Injury / Suspension
PLAYER STATUS
C.J. Stroud, QB INJURED
Denico Autry, DE INJURED
Will Anderson Jr., DE INJURED
Jamal Hill, LB INJURED
Jalen Pitre, S INJURED
Blake Fisher, OT INJURED
Trent Brown, OT INJURED

We'll Soon Know If the Colts Are For Real

Despite their hot start and status as a surprise team rife with great comeback stories, namely QB Daniel Jones, there have still been questions as to how "real" the Colts are.

Most of their wins were against bad teams. But they did defeat the Broncos and Chargers. In Week 12, they blew a 20-9 lead over the Chiefs with 8:37 remaining and lost in overtime.

At 8-3, they are in 1st place in the AFC South. But Jacksonville is nipping at their heels, and Houston is now 2 games back with 2 head-to-head games against each team in the stretch run.

Jones is dealing with a fractured fibula, but insists he will play.

With Jones compromised, particularly in his running ability, it will impact the entire offense, including all-world running back Jonathan Taylor. Taylor leads the league in yards, TDs, 1st downs, and yards rushing per game.

The Colts are 1st in points scored per game and 9th in points allowed per game. Their pass defense was a weak point, but they tried to address it by acquiring Sauce Gardner from the Jets.

Expect the Texans' ruthless defense to see exactly how injured Jones is.

Injury / Suspension
PLAYER STATUS
Daniel Jones, QB INJURED
Ashton Dunlin, WR INJURED

Texans vs Colts NFL Pick

In Week 13 Texans-Colts, Houston has its chance to make a serious run toward the AFC South title with a victory. They travel to Indianapolis on a hot streak, with their starting QB Stroud likely to return, and with Indy QB Jones playing on a fractured fibula. If they can corral Taylor, they have a great chance of winning the game.

This is a key game for the Colts. If they win, they will essentially end Houston's divisional hopes.

The underdog Texans will keep the game within the 3.5-point spread and have a good chance of winning it outright.

Pick
Houston Texans +3.5
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