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Jaguars vs Cardinals NFL Pick: Jags Seek to Stay Alive in Arizona (Nov 23)

Published Nov 21, 7:19pm ET by

Keith McCarthy - Betting Preview Analyst and Sports Writer

Last updated Nov 21, 7:19pm ET

Pick status
Oregon will play Michigan in the NCAAF on November 2

Updated Nov 21, 7:48pm ET

  • The Jaguars completely dominated the Chargers last week, surging to a 35-6 victory.
  • Arizona continued to struggle on Sunday, losing 41-22 to the 49ers and dropping to 3-7.
  • These two teams last met on September 26, 2021, in a game that the Cardinals won 31-19.

The Jaguars and Cardinals meet in an interconference battle on Sunday. Jacksonville is heating up at the right time in a competitive division, while Arizona's losing streak continues each week.

Arizona Cardinals vs. Jacksonville Jaguars Overview Watch On: CBS

DATE & TIME

SUNDAY, NOVEMBER 23, 2025 @ 4:05 PM ET
Arizona Cardinals
STATE FARM STADIUM
GLENDALE, AZ
Jacksonville Jaguars
GAME ODDS
BetOnline
Arizona Cardinals +3.0 (-105)
Jacksonville Jaguars -3.0 (-105)

Jaguars Fight to Keep Pace in AFC South

Jacksonville improved to 6-4 following their impressive thumping of the Chargers. It allowed them to keep pace in a division that also has the Colts (8-2) and Texans (6-5). The Jaguars didn't get any sacks and only forced one turnover in the 35-6 win, but were enormously clutch on 3rd and 4th downs. On offense, Trevor Lawrence had another pedestrian game, completing 14 of 22 passes for 153 yards, 1 TD, and 1 INT.

ALSO SEE: Jets vs Ravens | Week 12 Odds & NFL Pick (Nov 23)

Cardinals in Need of a Win to End Skid

Arizona has now lost 7 of their last 8 games since starting the season 2-0. It's been a complete collapse for a Cardinals team that is all but eliminated from contention. Kyler Murray's absence has made it difficult, but the defense has been the biggest issue. After allowing over 40 points for the second straight week, Arizona had to abandon their game plan to try and catch up, forcing Jacoby Brissett to throw 57 passes.

Jaguars vs Cardinals NFL Pick

Although the Cardinals have home-field advantage in this game, it's a bit surprising to see Jacksonville only favored by 3 points. They're coming off of a 29-point blowout victory over a Chargers team that is much better than the Cardinals. It's unlikely to be another massive point difference this week for the Jags, but they should have no trouble scoring on Arizona's flailing defense. Take Jacksonville to win and cover.

Pick
Jacksonville Jaguars -3.0
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