Jaguars vs Broncos NFL Pick: 2 of the AFC’s Best Meet in a Mile High Showdown (Dec 21)

Published Dec 18, 4:22pm ET by

Paul Lebowitz - Betting Preview Analyst and Sports Writer

Last updated Dec 18, 4:22pm ET

Pick status

Grok AI

Updated Dec 18, 4:22pm ET

  • For NFL Week 16 Jaguars-Broncos, two of the top teams in the AFC clash in Denver
  • Jacksonville (10-4) has won 5 straight and is in control of its destiny in the AFC South
  • If Denver (12-2) wins 2 of its last 3 games, it is guaranteed the #1 seed in the AFC for the playoffs
  • The teams last met in 2022, a 21-17 Broncos win in Jacksonville
Denver Broncos vs. Jacksonville Jaguars Overview Watch On: Fox

DATE & TIME

Sunday, December 21, 2025 @ 4:25 PM ET
Denver Broncos
Empower Field at Mile High
Denver, CO
Jacksonville Jaguars
GAME ODDS
BetOnline
Denver Broncos -3 (-115)
Jacksonville Jaguars +3 (-105)

The Jags' Remarkable Turnaround Continues

In Week 15, Jags' QB Trevor Lawrence played his best game of the season. Admittedly, it was against the Jets. But there's no way to "yeah, but" a passer rating of 136.7, completing 20 of 32 passes for 330 yards, 5 passing TDs, 1 rushing TD, and no interceptions.

The Jags took the Jets apart in their 48-20 win. They could have scored 60+ had they chosen to. Now, they're in the driver's seat to take the AFC South title one year after going 4-13.

Week 16 is a tough test as they visit Denver. But they have already beaten the 49ers, Chargers, Chiefs, and Texans this season. Their strength is in turnover differential (+10), and their rush defense, ranked 1st in the league in fewest rushing yards allowed per game.

For Lawrence, who was straddling the line of being a bust, his breakout season couldn't have come at a better time with stable leadership from rookie head coach Liam Coen and a strong supporting cast, particularly trade deadline acquisition Jakobi Meyers.

After Denver, the Jags play the spiraling Colts and the woeful Titans.

ALSO SEE: Raiders vs Texans | Week 16 Odds & NFL Pick (Dec 21)

Injury / Suspension
PLAYER STATUS
Danny Striggow, DE INJURED
Josh Hines-Allen, DE INJURED
Bhayshul Tuten, RB INJURED
Ezra Cleveland, G INJURED
Jalen McLeod, LB INJURED
Jack Kiser, LB INJURED
Walker Little, OT INJURED

The Broncos Have Won 11 Straight and Are Looking for the #1 Seed in the AFC

Despite the Broncos' run to the playoffs in 2024, no one expected them to be vying for the #1 seed in the AFC with a realistic pathway to the Super Bowl in 2025.

But here they are.

Sean Payton's team has won 11 straight games and could very well take that top seed. They still have a tough road ahead of them with games against the Jaguars, Chiefs, and Chargers.

KC has already been eliminated from playoff contention and QB Patrick Mahomes is lost for the season, so they have already checked out. The final game of the regular season against LA could be vital.

Denver has made a habit of staging come-from-behind victories. In Week 15, against the Packers, another top contender, they came from 23-14 down in the 3rd quarter to win 34-26.

QB Bo Nix completed 23 of 34 passes for 302 yards and 4 TDs. Denver's defense picked off Jordan Love twice, including a magical play by star cornerback Patrick Surtain II.

No part of the Broncos' package comes leaping off the statistical page, but they are efficient and play solid fundamental football. Naysayers will point to the number of close games they've played and how many times they've come from far behind with late rallies.

But the Chiefs did the same thing in 2024 and went all the way to the Super Bowl. By now, it might be time to believe the Broncos' results are legitimate rather than happenstance.

Injury / Suspension
PLAYER STATUS
Karene Reid, LB INJURED
Justin Strnad, LB INJURED
Brandon Jones, S INJURED
Ben Powers, G INJURED

Jaguars vs Broncos Pick

In Week 16 Jaguars-Broncos, two teams heading for the playoffs collide. Denver has an excellent pass rush and a never-say-die attitude. The Jaguars are gaining confidence week to week and riding Lawrence's rise to becoming what he was expected to be when he was selected first overall in the 2021 NFL Draft.

The Broncos do not want to see their momentum stop. The Jags have momentum of their own and with their AFC South rival Texans playing the horrible Raiders, Jacksonville needs to win to maintain first place in the division.

This will be a tight game coming down to the final minutes with the favored home team pulling it out and covering the spread.

Pick
Denver Broncos -3
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