Colts vs Jaguars NFL Pick: Indy and Jacksonville in a Dead Heat in the AFC South (Dec 7)

Published Dec 2, 10:40pm ET by

Paul Lebowitz - Betting Preview Analyst and Sports Writer

Last updated Dec 2, 10:40pm ET

Pick status

Grok AI

Updated Dec 2, 10:40pm ET

  • In NFL Week 14 Colts-Jaguars, two surprising 8-4 teams meet in Jacksonville with 1st place in the AFC South on the line
  • Indianapolis has lost 3 of 4 after a 7-1 start; they will be without newly acquired CB Sauce Gardner
  • Jacksonville has won 3 straight to pull even with Indy
  • The teams split their two matchups last season
  • They meet again in Week 17
Jacksonville Jaguars vs. Indianapolis Colts Overview Watch On: CBS

DATE & TIME

Sunday, December 7, 2025 @ 1:00 PM ET
Jacksonville Jaguars
EverBank Stadium
Jacksonville, FL
Indianapolis Colts
GAME ODDS
BetOnline
Jacksonville Jaguars +1 (+103)
Indianapolis Colts -1 (-123)

This is the 1st of 5 Rough Games for Indy

After the Colts' stunningly hot start with reclamation project QB Daniel Jones leading the way, they became a trendy Super Bowl pick. That has subsided in the past four weeks with losses to the Steelers, Chiefs, and Texans, plus barely squeaking by the Falcons in overtime.

Still, they're 8-4 and in a good position to make the playoffs even if they don't win the division. Jacksonville has caught them in the division, and Houston is right behind both and playing excellent football after a terrible start.

In Week 13, Houston traveled to Indianapolis and beat the Colts 20-16. The Colts were doomed by a missed Michael Badgley extra point attempt in the second quarter. The Colts cut Badgley on Tuesday.

They signed Blake Grupe to replace him.

Jones played with a fractured fibula and completed 14 of 27 passes for 201 yards and 2 TDs. But he didn't run. That takes away a fundamental part of his game and makes him a pure pocket passer.

Jacksonville is first in the league in defensive rushing yards per game, so Jones will need to pass to win. Indy will be without cornerback Sauce Gardner, out with a calf injury.

After Jacksonville, the Colts play the Seahawks, 49ers, Jaguars again, and Texans. If they lose this game, winning the division will be difficult.

ALSO SEE: Commanders vs Vikings Week 14 Odds & NFL Pick (Dec 7)

Injury / Suspension
PLAYER STATUS
Sauce Gardner, CB INJURED

With a Win, the Jags Are the Division Favorites

The Jaguars' 8-4 record has not been based on a weak schedule. Sure, they have victories over the Raiders, Cardinals, and Titans, but they've also beaten the Chiefs, 49ers, and Chargers. Even their win over the Panthers is looking more impressive as Carolina rises to playoff contention in their own right.

The teams are in a dead heat at the moment. With the Texans right on their heels, the schedule will come into play, and the Jags' schedule is the easiest, on paper.

In their Week 13 win over the woeful Titans, QB Trevor Lawrence completed 16 of 27 passes for 2 TDs. Jakobi Meyers caught 6 balls for 90 yards and a TD.

Josh Hines-Allen sacked Cam Ward twice.

On paper, these teams are very evenly matched. Both are good against the run and vulnerable to the pass. With Gardner out, expect Lawrence to open it up and push the ball downfield. He's prone to throwing interceptions, so the game could come down to turnovers.

Injury / Suspension
PLAYER STATUS
Travon Walker, DE INJURED
Patrick Mekari, G INJURED
Chuma Edoga, G INJURED
Arik Armstead, DT INJURED
Walker Little, OT INJURED
Parker Washington, WR INJURED

Colts vs Jaguars NFL Pick

For Week 14 Colts-Jaguars, barring a tie, one team will walk off the field in sole possession of first place in the AFC South. Indianapolis desperately needs this victory to restore its confidence after a rough stretch amid injuries and bad luck. Jacksonville will have taken a major step forward after a 4-13 season in 2024.

If the Jags win, they have a relatively clear path to the division title. It's conceivable that the Colts will end up in third place in the division.

This will be a tight battle with road favorite Indianapolis taking the win and with it, first place.

Pick
Indianapolis Colts -1
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