Jaguars vs 49ers NFL Pick: San Francisco Eyes 4-0 Start (Sep 28)

• Jacksonville held off the Texans last week, defeating them by a score of 17-10.
• The 49ers won a thriller against the Cardinals, winning 16-15 in the final seconds.
• These two teams last met on November 12, 2023, in a game that the 49ers won 34-3.

San Francisco hosts the 2-1 Jaguars this week as both teams attempt to continue rising in the standings. This game shapes up to be a low-scoring, defensive battle, with the 49ers holding a slight edge at home.

Jaguars Seeking Upset Victory

The Jaguars won a sloppy game against the Texans on Sunday, improving to 2-1 overall. It’s a solid start for Jacksonville, though they are facing some concerns on offense. QB Trevor Lawrence ranks in the bottom-10 in QBR, struggling to take the step forward under new head coach Liam Coen that many were hoping for. On other side of the ball, the Jaguars have improve massively, giving them an asset to work with this week.

49ers Aim for 4-0 Start

San Francisco won a thrilling battle between 2-0 teams against the Cardinals last week, earning a spot amongst the NFL’s final unbeaten teams. They’ll aim to continue that trend this week against Jacksonville. The 49ers have a notable advantage with a skilled defense, though the season-ending injury to Nick Bosa is sure to have some massive repercussions. They’ll aim to win against the Jaguars on Sunday in his absence.

Jaguars vs 49ers NFL Pick

Despite holding similar records at 2-1 and 3-0, the Jaguars and 49ers are not that evenly matched. Jacksonville has not looked nearly as impressive as their record and is sure to struggle offensively on the road in this game. Even without Nick Bosa, San Francisco will likely cause trouble for Trevor Lawrence and company. Backup QB Mac Jones should be able to do just enough to get the 49ers a low-score victory.