College Football Picks

South Carolina Gamecocks vs Virginia Tech Hokies

08/31/2025 3:00 PM ET

PICK – Spread:

South Carolina -8.0

South Carolina and Virginia Tech face off in an SEC/ACC battle in Atlanta. The Gamecocks are hoping to crack the CFP this season, and need to start the year with a win over the scrappy Hokies.

Keith McCarthy – Pick Made 1 week ago Read Full Analysis

Florida State Seminoles vs Alabama Crimson Tide

08/30/2025 3:30 PM ET

PICK – Spread:

Alabama Crimson Tide -13.5

Alabama is looking to bounce back after missing the CFP last season. They'll face a Florida State team that is seeking a redemption tour of their own after a wildly disappointing season.

Keith McCarthy – Pick Made 1 week ago Read Full Analysis

Syracuse Orange vs Tennessee Volunteers

08/30/2025 2:00 PM ET

PICK – Spread:

Syracuse Orange +14.5

Syracuse and Tennessee meet in their opener in a battle of orange-colored teams. The Volunteers narrowly stayed inside the top-25 and will aim to prove themselves against Syracuse.

Keith McCarthy – Pick Made 1 week ago Read Full Analysis

Miami Hurricanes vs Notre Dame Fighting Irish

08/31/2025 7:30 PM ET

PICK – Spread:

Notre Dame -2.5

The defending runners-up head to #10 Miami in their 2025 opener. Notre Dame enters with a slight edge against a Hurricanes team that no longer has phenom QB Cam Ward.

Keith McCarthy – Pick Made 2 weeks ago Read Full Analysis

Clemson Tigers vs LSU Tigers

08/30/2025 7:30 PM ET

PICK – Spread:

LSU +4.5

LSU and Clemson meet in the opening week of the season for a top-10 clash. Both teams are CFP hopefuls, with the winner claiming the spot as the nation's best "Tigers".

Keith McCarthy – Pick Made 2 weeks ago Read Full Analysis

Ohio State Buckeyes vs Texas Longhorns

08/30/2025 12:00 PM ET

PICK – Spread:

Ohio State -2.5

Ohio State and Texas open the season in a rematch of last year's Cotton Bowl Semifinal Game. The Longhorns are seeking revenge against the Buckeyes, opening ranked #1.

Keith McCarthy – Pick Made 2 weeks ago Read Full Analysis

Iowa State Cyclones vs Kansas State Wildcats

08/23/2025 12:00 PM ET

PICK – Spread:

Kansas State -3.5

Iowa State and Kansas State meet in Dublin, Ireland for a conference rivalry clash. Both teams are dealing with some roster turnover, making this an intriguing clash in the wide-open Big-12.

Keith McCarthy – Pick Made 2 weeks ago Read Full Analysis