Rockies vs Guardians MLB Pick: Interleague Battle in Cleveland (Jul 29)

Interleague action continues on Tuesday, July 29, 2025, as the Colorado Rockies (28-78) face the Cleveland Guardians (52-54) at Progressive Field in Cleveland, Ohio. First pitch is scheduled for 6:40 p.m. ET. After the Rockies surprisingly took Game 1 of this series, the Guardians will be eager to bounce back at home.

Colorado Rockies Outlook

The Rockies continue to navigate a challenging season, holding a 28-78 record, last in the NL West. Despite their struggles, their offense has some power with 102 home runs. Hunter Goodman (18 HR, 57 RBI) is a key slugger. They recently secured an unexpected 8-6 win in Game 1 of this series.

Injury Update: Kris Bryant (back) remains on the 60-day IL. German Marquez (shoulder) and Zach Agnos (hand) are also on the IL.

Cleveland Guardians Outlook

The Guardians are 52-54, sitting second in the AL Central. Their offense ranks 26th in MLB in runs per game but is powered by Jose Ramirez (21 HR, 56 RBI). Cleveland’s strength often lies in its pitching and defense, though they’ve faced numerous injuries on the mound. They will be highly motivated after dropping Game 1 at home.

Injury Update: The Guardians have several key pitchers sidelined, including Shane Bieber (UCL tear), Ben Lively (Tommy John), and Trevor Stephan (UCL reconstruction), all out long-term or for extended periods.

Analysis and Pick

The Guardians are heavy favorites at home, despite their Game 1 loss. Logan Allen is the more experienced starter against the Rockies’ struggling lineup, and Cleveland’s bullpen is generally reliable. The Guardians’ strong desire to even the series against a weak Colorado team should fuel their performance. Expect a disciplined effort from Cleveland to secure the win.