49ers vs Rams NFL Pick: An NFC West Clash on Thursday Night (Oct 2)

• The 49ers took their first defeat last week, falling to the Jaguars by a score of 26-21.
• Los Angeles won on Sunday against the unbeaten Colts, climbing to 3-1 on the year.
• These two teams last faced off on December 12, in a game that the Rams won 12-6.

The 49ers and Rams meet this week in a division rivalry bout. Both squads are 3-1, seeking to improve to 4-1 after this game. San Francisco has been battling through injuries, putting them as an underdog this week.

49ers Fighting Through Injuries

The 49ers got Brock Purdy back at QB last week, but continue to deal with injuries across the board. Despite Purdy’s return, San Francisco was unable to hold off the Jaguars at home. Their defense had a rare poor performance, which they’ll aim to bounce back from this week. On the other hand, the 3-1 49ers are well on the path to the postseason with a very competitive roster, despite taking their loss to the Jaguars.

Rams Seek Win over Rivals

The Rams climbed to 3-1 with a win over the previously unbeaten Colts. They enter this game with an opportunity to keep up their momentum and takeover the top spot in the division with a win. Los Angeles has won three consecutive games against the 49ers, after losing 9 out of 10 prior to 2024. Puka Nacua is on pace to break the reception and receiving yards records, leading the Rams in their NFC West title pursuit.

49ers vs Rams NFL Pick

The 49ers and Rams meet in a key divisional battle this week. Both teams are 3-1 and capable of winning here, which should make this a competitive matchup. Surprisingly the Rams are favored in the spread by over a touchdown. After their last four matchups came down to one score, the 49ers are a good bet to keep this close enough to cover. Expect this game to come down to closer to a field goal margin in Los Angeles.