Padres vs Red Sox MLB Odds, Picks, and Predictions (Apr 4)

Published Apr 3, 9:50pm ET by

Paul Lebowitz - Betting Preview Analyst and Sports Writer

Last updated Apr 3, 9:50pm ET

Pick status

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Updated Apr 3, 9:50pm ET

  • It's Padres vs Red Sox in this MLB interleague matchup
  • Boston (2-5) starts top pitching prospect, lefty Connelly Early
  • San Diego (2-5) sends righty Randy Vasquez to the hill
  • Both teams have gotten out of the gate slowly and need to rack up some wins
Boston Red Sox vs. San Diego Padres Overview Watch On: NESN, Padres.TV

DATE & TIME

Saturday, April 4, 2026 @ 4:10 PM ET
Boston Red Sox
Fenway Park
Boston, MA
San Diego Padres
GAME ODDS
BetOnline
Boston Red Sox -143
San Diego Padres +130

Boston Tries to String Together Some Wins Behind Early

The Red Sox got a much-needed win in their home opener against the Padres. They sit at 2-5, already 4 games behind the Yankees in the AL East.

For the second game of the set, they send top prospect Connelly Early to the mound at Fenway Park.

Early, who celebrated his 24th birthday on April 3, had an excellent spring training and continued that trend in his first regular season start. Against the Reds, he tossed 5.1 innings, allowed 5 hits, 1 earned run, walked 2, and struck out 6. He suffered a hard luck loss.

Boston has been almost universally inept at the plate so far. But Wilyer Abreu has 11 hits in 28 at-bats and 3 homers. Marcelo Mayer is hitting .294 with a 1.015 OPS.

The rest of the lineup has not been so fortunate. Roman Anthony is hitting .231, Willson Contreras is at .174, Trevor Story is hitting .121, Caleb Durbin is at .045. And so on.

They'll eventually start hitting, but this is obviously not how they wanted to break out of the gate after so many changes over the winter.

Boston has limited exposure to Padres starter Randy Vasquez. Abreu is 1 for 3. Contreras is 1 for 3 with a double. Jarren Duran is 1 for 2 with a single.

Vasquez Goes For His 2nd Straight Big Time Start

Padres righty Randy Vasquez established himself as a reliable starter in 2025 with a 2.3 bWAR in 28 appearances (26 starts). With the Padres not as star-studded as they've been in the recent past, they need Vasquez to continue that trend.

In his first start of 2026, he threw 6 innings, allowed 2 hits, walked 3, and struck out 8 in a win over the Tigers.

The Padres are in a tough division and have not hit early this season. Catcher Freddy Fermin is hitting a pathetic .071. Gavin Sheets is at .176. Xander Bogaerts is hitting .167. Fernando Tatis Jr. is hitting .238 with a .646 OPS.

Ramon Laureano is hitting .389 with 2 homers.

The Padres have never faced Early.

Padres vs Red Sox

Both the Padres and Red Sox are having slow starts. The difference is that the Red Sox have the manpower and expectations to hit much better than they have. For the Padres, it is more of a question. Their starting rotation is short and the lineup is mediocre at best.

Early will overpower the Padres and give the Red Sox their second straight win in this series.

Pick
Boston Red Sox -1.5 (+153)
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