Orioles vs Pirates MLB Odds, Picks, and Predictions (Apr 3)

Published Apr 2, 8:51pm ET by

Paul Lebowitz - Betting Preview Analyst and Sports Writer

Last updated Apr 2, 8:51pm ET

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Updated Apr 2, 8:51pm ET

  • It's Orioles-Pirates in Pittsburgh's 2026 MLB home opener at PNC Park
  • Both teams have started the season at 3-3
  • Baltimore sends Kyle Bradish to the mound against Pittsburgh's Mitch Keller
Pittsburgh Pirates vs. Baltimore Orioles Overview Watch On: SportsNet Pittsburgh, MASN

DATE & TIME

Friday, April 3, 2026 @ 4:12 PM ET
Pittsburgh Pirates
PNC Park
Pittsburgh, PA
Baltimore Orioles
GAME ODDS
BetOnline
Pittsburgh Pirates +111
Baltimore Orioles -122

Bradish Is Back for His 1st Full Season After TJ Surgery

Kyle Bradish missed much of the 2024 and 2025 seasons after undergoing Tommy John surgery. In 2023, he was a linchpin in the Orioles' rotation with a 4.8 bWAR, finishing 4th in the AL Cy Young Award voting. He was effective in his 2025 return, making 6 starts, posting a 2.53 ERA, and a 1.2 bWAR.

In his first start of the season, he tossed 4.2 innings, allowed 2 hits, 2 earned runs, 1 homer, walked 3, and struck out 4.

At the plate, the Orioles have been inconsistent thus far. New 1st baseman Pete Alonso is hitting .304 with an .819 OPS and a home run. Taylor Ward is hitting .333, as is Colton Cowser. Adley Rutschman is batting .286 with 3 doubles.

Tyler O'Neill is hitting .143 with a homer. Gunnar Henderson is batting .160 with a home run.

Against Pirates starter Mitch Keller, Alonso is 1 for 15. O'Neill is 3 for 15 with a double. Ward is 2 for 7.

Keller Tossed 6 Scoreless Innings in His 1st 2026 Start

The Pirates' hopes for 2026 rest largely on their starting rotation, led by Paul Skenes and #2 starter Mitch Keller.

Keller is a former All-Star who has become a reliable innings eater, throwing at least 159 innings every season since 2022. He can be much more than a mid-rotation arm, as he showed in his first 2026 start against the Mets. In 6 innings, he allowed 3 hits, walked none, and struck out 3.

Newly acquired Brandon Lowe has been searing at the plate with a .333 average, a 1.343 OPS, and 3 homers. Oneil Cruz is hitting .304 with a 1.029 OPS and 3 homers. Ryan O'Hearn is batting .421 with 2 homers. Nick Gonzales is batting .333 with 2 doubles.

Marcell Ozuna has gotten off to a horrible start, batting .050. Spencer Horwitz is batting .133 with a .321 OPS.

Against Bradish, Cruz is 1 for 3 with a single. Lowe is 3 for 10 with a double. Ozuna is 1 for 2 with a home run. Bryan Reynolds is 1 for 5.

Orioles vs Pirates Pick

The Pirates have made moves to try to excite their fan base and have shown improvement so far this season. However, they've gotten off to good starts in the past and fallen into a familiar terribleness.

However, Keller is a solid arm. The Orioles have been up-and-down at the plate and Bradish is still working back to his previous form.

The Pirates will take their home opener over the Orioles behind Keller.

Pick
Pittsburgh Pirates +111
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