#7 Kentucky vs #2 Iowa State NCAAB Pick: Wildcats Look to Crash the Sweet 16 in St. Louis (Mar 22)

Published Mar 22, 2:47am ET by

Demilade Adelekun - Betting Preview Analyst and Sports Writer

Last updated Mar 22, 2:47am ET

Pick status

Updated Mar 22, 3:07am ET

  • Kentucky survived Santa Clara 89-84 in overtime.
  • Iowa State demolished Tennessee State 108-74 in the first round.
  • Kentucky leads the all-time 3-0 series.

Oweh just had one of the great March Madness performances of the decade. Can he take Kentucky back to the second weekend?

Kentucky Wildcats vs. Iowa State Cyclones Overview Watch On: CBS

DATE & TIME

Sunday, March 22, 2026 @ 2:25 PM ET
Kentucky Wildcats
Enterprise Center
St. Louis, MO
Iowa State Cyclones
GAME ODDS
BetOnline
Kentucky Wildcats +190
Iowa State Cyclones -230

Oweh Is Playing Like a Man Possessed

Kentucky is 22-13 overall and the 7th seed in the Midwest Region — the program's lowest seed since 2014.

For More March Madness Betting Odds and Predictions, See the Full Hub

Otega Oweh was unreal against Santa Clara. Along with hitting a buzzer-beater to send the Wildcats into OT, Oweh just joined Oscar Robertson, Bill Bradley, and Larry Bird as the only players in NCAA Tournament history to post 35 points, 8 rebounds, and 7 assists in a single game.

No Jefferson No Problem

Iowa State is 28-7 overall and the 2nd seed in the Midwest Region. They are looking for their eighth Sweet 16 in program history and third under TJ Otzelberger. He has made the cyclones one of the best programs in the country since taking the head coach job.

Joshua Jefferson's ankle injury is the story. He left the first round game because of this. This was a major blow for the cyclones, but they still look dominant as ever. Iowa State ranked 6th in both KenPom and NET this season. Even without Jefferson, this is a top-10 team.

#7 Kentucky vs #2 Iowa State NCAAB Pick:

Kentucky vs Iowa State will be a fun one. With that said, Iowa State is the better team, and Momcilovic is capable of carrying them even without Jefferson. They're deeper, more efficient, and built for exactly this kind of game. We expect their defense to carry them to a win. Our pick is Iowa State (-230).

Pick
Iowa State (-230)
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