#4 Arizona vs #2 Houston NCAAB Pick: Top 5 Showdown (Feb 21)

Published Feb 20, 9:41am ET by

Demilade Adelekun - Betting Preview Analyst and Sports Writer

Last updated Feb 20, 9:41am ET

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  • Arizona is coming off a 75-68 win against BYU on Wednesday.
  • Houston recently lost 70-67 to Iowa State on Monday.
  • The last time Houston and Arizona met, Houston won 72–64 to claim the 2025 Big 12 Championship title

Arizona travels to Houston in a potential foreshadowing of the Big 12 title game. The winner of this game will control first place in the conference.

Houston Cougars vs. Arizona Wildcats Overview Watch On: ABC

DATE & TIME

SATURDAY, FEBRUARY 21, 2026 @ 3:00 PM ET
Houston Cougars
Feritta Center
Houston, TX
Arizona Wildcats
GAME ODDS
BetOnline
Over 139.5 (-110)
Under 139.5 (-110)

Another Ranked Foe for Arizona

Arizona is 24-2 overall and 11-2 in Big 12 play. Arizona, currently 4th in the AP Poll, started the season 23-0, but after a tough slate of games, they have dropped two. The Wildcats are still slated as a 1 seed in March Madness.

This game will be the fourth straight ranked opponent for Arizona, and arguably the most formidable. The Big 12 is known to be a gauntlet, and the Wildcats schedule is a testament to that. This game will likely determine the winner of the regular-season championship.

Houston's Title Push

Houston is 23-3 overall and 11-2 in Big 12 play, currently ranked 2nd in the AP poll, and slated as a 1 seed in March Madness. For More March Madness Betting Odds and Predictions, see the Full Hub.

Since moving into the Big 12, they have controlled it. With back to back conference and tournament championship, Kelvin Sampson and crew eye to make it a three-peat. Coming off a loss to ISU, Houston will look to bounce back and secure their spot on top.

#4 Arizona vs #2 Houston NCAAB Pick


Arizona vs Houston will be a blockbuster event. We believe that Arizona is going dictate the tempo of the game. They love getting up and down. Houston likes to play slower, but has the offensive capabilities to manage a shootout. Our pick is to take the over (139.5)

Pick
Over (139.5)
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