#15 Missouri vs #10 Vanderbilt NCAAF Pick: SEC Battle in Nashville (Oct 25)

Published Oct 23, 12:52am ET by

Gabriel Kozlow - Betting Preview Analyst and Sports Writer

Last updated Oct 23, 12:52am ET

Pick status
Oklahoma State will play BYU in the NCAAF on October 18

Updated Oct 23, 12:52am ET

  • #15 Missouri (6-1) is coming off an OT win 23-17 versus Auburn.
  • #10 Vanderbilt (6-1) beat LSU 31-24 in Week 8.
  • This matchup's last meeting was on September 21st, 2024, with a Missouri victory 30-27.

Missouri Tigers and Vanderbilt Commodores have played against each other 17 times, with the Tigers having the edge 12-4-1. This will be a huge test for both teams as they are striving for power in the SEC. The game will be played on Vanderbilt's turf at FirstBank Stadium.

VANDERBILT COMMODORES vs. MISSOURI TIGERS Overview Watch On: ESPN

DATE & TIME

SATURDAY, OCTOBER 25, 2025 @ 1:30 PM ET
VANDERBILT COMMODORES
FirstBank Stadium
Nashville, TN
MISSOURI TIGERS
GAME ODDS
BetOnline
VANDERBILT COMMODORES -145
MISSOURI TIGERS +125

Tigers Ready to Reassert Dominance

Missouri's sole loss this season was only by a field goal and against Alabama, they rest of the games they have dominated. They did get a scare versus Auburn this past week as they went to two overtime sessions with the Tigers coming out on top.

The SEC standings have Texas A&M leading the way with Alabama close by. If Missouri win this game they'll jump to 3-1 in the conference and a 7-1 overall, almost surely will jump in the rankings. They are slight underdogs for this one at +2.5.

Commodores Seek Breakthrough Moment

The Vanderbilt Commodores have an interesting thing in common with Missouri, both teams have lost once this season, and both lost it to Alabama. Nonetheless, whoever wins this game this weekend will assert themselves over their rival in the standings. Vanderbilt is ranked higher in this SEC showdown, but a win in front of their home crowd will be huge.

Vanderbilt's QB Diego Pavia has had 15 TDs with only 4 INTs, he also has 1,569 total passing yards, so let's expect him to be aggressive for this one. Let's not forget he also has 4 TDs rushing with a total of 438 rushing yards. So, what we mean with all these stats is that if he has a great game, they'll probably win.

#15 Missouri vs #10 Vanderbilt NCAAF Pick

Vanderbilt is playing at home, and they are slight favorites with a -2.5 spread. The over/under is 51.5, so expect both teams to get on the board. The money line for the Commodores is -145, with the Tigers at +125.

Our pick for this game is for the home team, as we feel Vanderbilt will win the game. We think that Diego Pavia will have an awesome game and set the tone early on. Both teams are in for a battle though, so we promise it will be a close one.

Pick
Vanderbilt -2.5
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