The fascinating semi-finals at the US Open are set for this week. Amanda Anisimova will be bidding to set up an all-American clash with Jessica Pegula at Flushing Meadows. However, Naomi Osaka will have her sights set on a third US Open title. You can find the odds and picks here.

Naomi Osaka vs. Amanda Anisimova Overview

StatInformation
Date & TimeThursday, September 4, 2025 @ 9:00 PM ET
WhereArthur Ashe Stadium, New York
How to WatchESPN

Odds

Match ResultOdds
Naomi Osaka-125
Amanda Anisimova+100

Naomi Osaka vs. Amanda Anisimova Head-to-Head Record

TotalOsakaAnisimova
Wins202
Hard Court Games101

A third career meeting is set between Anisimova and Osaka this week. The American has won each of the previous two encounters, with both coming in the 2022 season.

Match Preview

A story of comebacks will create the narrative of the semi-final between Osaka and Anisimova on Thursday. The American bounced back from a history-making defeat in the Wimbledon final to overcome Iga Swiatek in the previous round, banishing the ghosts with an eye-catching straight sets win against the multiple-time Grand Slam winner.

Anisimova may have been fearing the worst after losing the opening game, but she quickly responded to take the first set. Her dominance continued into the second set, dropping just three games to book her spot in the final four of the Slam.

Naomi Osaka has also achieved a career renaissance at the US Open this summer, and she will be aiming to win a Grand Slam title for the sixth time in her career. Osaka has overcome seeded players in each of the last three rounds, which includes a clinical showing against Karolina Muchova on Wednesday.

The Japanese player registered five aces, and was able to convert on three of four break point opportunities. However, it could be argued that this challenge against Anisimova will be her most difficult to date.

Naomi Osaka vs. Amanda Anisimova Picks

We have been huge admirers of Anisimova throughout the season, and everything appears to have fallen into place in her pursuit of a Grand Slam title. We expect her excellent form to continue on Thursday by achieving a straight sets win against Osaka.

Pick
Amanda Anisimova (+100)
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US Open Women’s Semi-Final Picks

MatchPick
Aryna Sabalenka vs. Jessica PegulaAryna Sabalenka

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Alex Dudley
Alex Dudley

Sports Analyst and Betting Expert

Alex has over 15 years of experience in sports betting, specializing in soccer and horse racing. He uses his deep knowledge of markets and strategies to guide readers through disciplined and informed betting.

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