San Diego vs. Minnesota MLS Picks: Hosts to Ease into First Conference Finals? (Nov 24)

Published Nov 13, 4:38am ET by

Alex Dudley - Betting Preview Analyst and Sports Writer

Last updated Nov 13, 4:38am ET

Pick status
The MLS Conference Semi-Finals continue on Nov 24, 2025. Find the odds and our San Diego vs. Minnesota picks here.

Credit: Shutterstock

Updated Nov 13, 4:38am ET

  • San Diego FC have dominated the Western Conference in 2025
  • Minnesota United upset the odds to eliminate the Seattle Sounders in the opening round

The final Conference semi-final to be staged is set for San Diego on Nov 24. You can find the odds and our San Diego vs. Minnesota picks here.

San Diego have been the standout team in the Western Conference throughout 2025, and they could win the MLS Cup in their first campaign. They eased through to the semi-final stage after beating the Portland Timbers twice at home.

Meanwhile, Minnesota upset the odds in the opening round of the playoffs after holding their nerve in a penalty shootout against the Seattle Sounders. But, could they spring a second upset in the playoffs?

San Diego FC vs. Minnesota United Overview Watch On: Apple TV

DATE & TIME

Monday, November 24, 2025 @ 10:00 PM ET
San Diego FC
Snapdragon Stadium, San Diego
Minnesota United
GAME ODDS
BetOnline
San Diego FC -168
The Draw +339
Minnesota United +413

San Diego Chasing MLS History

It has been a remarkable first season in the MLS for San Diego FC. Tyler Heaps has made the team an immediate force at the highest level, topping the Western Conference standings at the end of the regular season campaign after winning 19 of their 34 games.

Their spot in the semi-finals of the playoffs was assured following a Game Three win over the Portland Timbers on Nov 9. Andres Dreyer and Amahi Pellegrino both scored two goals apiece in the home win.

However, a notable concern would be their away record, winning just nine of their 19 matches.

Possible Lineup
(4-3-3) Sisniega (GK); Pilcher, McVey, Duah, Bombino; Valakari, Tverskov, Godoy; Dreyer, Baird, Pellegrino

United Chasing Another Upset

Minnesota United are one of the sides that have been overlooked in the grand scheme of the playoffs this season.

Few expected them to overcome the Seattle Sounders in the opening round, but they held their nerve in two penalty shootouts. United showed their character in the Game Three win, as they were forced to play the entire second half with ten men.

However, the expansive counter-attack style almost saw them gain the victory inside 90 minutes. That character will make them a solid chance this weekend, but they will be up against it against one of the best teams in the Western Conference.

Possible Lineup
(4-4-2) St Clair (GK); Diaz, Boxall, Duggan, Gene; Lod, Triantis, Trapp, Pereyra; Hlongwane, Yeboah
San Diego vs. Minnesota Head-to-Head Record
TOTAL San Diego Minnesota DRAWS
Games 2 5 5 0
Goals 10 5 5

San Diego vs. Minnesota Picks

The previous meetings between these sides have been very competitive affairs, with ten goals scored across the two encounters.

However, San Diego’s reliable form in the MLS throughout this season could be challenging to overlook in the semi-final stage. Therefore, a home win is preferred when making San Diego vs. Minnesota picks.

Pick
San Diego (-168)
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