Portland Timbers vs. Real Salt Lake MLS Picks: Western Conference Wild-Card Showdown Set (Oct 22)

Published Oct 20, 5:21am ET by

Alex Dudley - Betting Preview Analyst and Sports Writer

Last updated Oct 20, 5:21am ET

Pick status
The Western Conference wild-card round is set for Oct 22. Find the MLS odds and our Portland Timbers vs. Real Salt Lake picks here.

Credit: Shutterstock

  • Portland Timbers and Real Salt Lake finished eighth and ninth, respectively, in the Western Conference standings
  • The winner of this clash will take on San Diego FC in Round One of the MLS playoffs

Business picks up in the MLS this week, as the wild-card rounds in the Eastern and Western conferences are set. You can find the odds and our Portland Timbers vs. Real Salt Lake picks for the latter here.

The Portland Timbers ended the regular campaign in a place and three points higher than Real Salt Lake.

Meanwhile, the visitors on Wednesday snuck into the wild-card round courtesy of their superior number of wins over the San Jose Earthquakes.

Portland Timbers vs. Real Salt Lake Overview Watch On: Apple TV

DATE & TIME

Wednesday, October 22, 2025 @ 10:30 PM ET
Portland Timbers
Providence Park, Portland
Real Salt Lake
GAME ODDS
BetOnline
Portland Timbers +116
The Draw +265
Real Salt Lake +220

Timbers Have Pressure on Their Shoulders

The increased pressure this week will likely be on the Portland Timbers, who went 11-12-11 in the regular season to finish eighth in the Western Conference.

However, their recent form would be a major concern after losing each of their last two without scoring.

Their most recent defeat was a 4-0 loss at the hands of San Diego FC. Despite this, the Timbers have won 41% of their home matches in 2025.

Possible Lineup
(4-2-3-1) Pantemis (GK); Mosquera, Surman, Zuparis, Miller; Rojas, Ayala; Antony, Costa, Velde; Mora

Visitors in Reliable Form

Real Salt Lake could be the in-form team in the wild-card round. They ended the regular season on a positive note after taking four points from their last three games.

However, they will need to bounce back after throwing away a 2-0 advantage on the final day of the campaign against St. Louis.

It could be worth noting that Real Salt Lake have underperformed on the road throughout the season, winning just 18% of their games and scoring a low average of 0.88 goals per game.

Possible Lineup
(4-2-3-1) Cabral (GK); Yedlin, Glad, Vera, Junqua; Caliskan, Ojeda; Gozo, Luna, Goncalves; Olatunji
Portland Timbers vs. Real Salt Lake Head-to-Head Record
TOTAL Portland Real Salt Lake DRAWS
Games 47 18 16 13
Goals 143 77 66

Portland Timbers vs. Real Salt Lake Picks

Real Salt Lake's poor form on the road is a notable concern ahead of this wild-card showdown on Wednesday.

However, they have avoided defeat in their last three against the Timbers. An extremely cagey affair is expected this week, but the narrow preference is for the hosts to make their quality count.

Pick
Portland Timbers (+116)
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