Eastern Conference Final: Inter Miami vs. New York City FC MLS Picks: Messi to Fire Inter Into MLS Cup Final? (Nov 29)

Published Nov 24, 5:32am ET by

Alex Dudley - Betting Preview Analyst and Sports Writer

Last updated Nov 24, 5:32am ET

Pick status
The MLS Eastern Conference Finals are set for Nov 29, 2025. Find the odds and our Inter Miami vs. New York City FC Picks here.

Credit: Shutterstock

Updated Nov 24, 5:32am ET

  • Inter Miami competing in their first ever Eastern Conference Final
  • New York City upset the odds in the previous round to overcome Philadelphia

Just two teams remain in the hunt for MLS Cup glory in the Eastern Conference. Inter Miami and New York City FC collide in the MLS Playoffs on Nov 29, and you can find our picks here.

Lionel Messi's Inter Miami have been the favorites for MLS Cup glory throughout the campaign, and they showcased their quality with a straightforward 4-0 win over FC Cincinnati on Sunday.

Meanwhile, NYC will bring momentum into this round following a stunning win in the previous round to overcome Philadelphia.

Inter Miami vs. New York City FC Overview Watch On: Apple TV

DATE & TIME

Sunday, November 29, 2025 @ 6:00 PM ET
Inter Miami
Chase Stadium, Miami
New York City FC
GAME ODDS
BetOnline
Inter Miami -223
The Draw +350
New York City FC +475

Inter Have Important Home Field Advantage

It could be argued that Inter Miami are peaking at the perfect stage of the season.

Javier Mascherano's side produced one of their best displays of the season in the previous round, as they hammered FC Cincinnati 4-0 away from home. Inter dominated the ball, and pulled clear of their opponents in the second period after netting three goals in 25 minutes.

Messi was once again at the heart of the team, scoring the opener, and having a hand in two of the second half efforts.

ALSO SEE: Champions League Matchday 5 Picks & Preview (Nov 25-26)

Possible Lineup
(4-3-3) Novo (GK); Weigandt, Falcon, Allen, Alba; De Paul, Allende, Busquets; Messi, Suarez,Rodriguez

NYC To Produce Shock?

New York City have enjoyed an excellent run to the conference finals this season.

They defied expectations in the previous round to overcome Philadelphia. NYC appeared happy to play without the ball, and they constantly looked to hit their opponents on the counter-attack. Their only effort was scored in the opening 30 minutes, with Maximiliano Moralez producing the moment of magic in the 27th minute.

A similar approach is likely in Miami this weekend, and they will aim to be clinical when creating chances on the counter.

Possible Lineup
(5-4-1) Freese (GK); Wolf, Gray, Haak, Martins, O’Toole; Moralez, O’Neill, Perea, Fernandez; Martinez
Inter Miami vs. NYC Head-to-Head Record
TOTAL Inter Miami NYC DRAWS
Games 14 2 8 4
Goals 40 16 24

Inter Miami vs. New York City FC Picks

This will be a fascinating showdown in the Eastern Conference finals. New York's defensive record deserves huge respect, and they have the tactical know-how to make this a stern test for Inter.

We like their chances of winning this game, as their counter-attack style could be perfect against an aging Inter midfield, which lacks mobility.

Pick
New York City FC (+475)
New Player Bonus
50% up to $1000