Inter Miami vs. Nashville SC MLS Picks: Messi to Fire Hosts to Game One Victory? (Oct 24)

Published Oct 21, 4:00am ET by

Alex Dudley - Betting Preview Analyst and Sports Writer

Last updated Oct 21, 4:00am ET

Pick status
The first-round of the MLS playoffs gets underway this weekend. Find our Inter Miami vs. Nashville SC picks here.

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Updated Oct 21, 4:00am ET

  • Inter Miami finished third in the Eastern Conference standings after going 19-8-7
  • Nashville concluded the regular season in sixth place in the Eastern Conference

The serious business of the MLS playoffs gets underway this weekend, as the first games in a three-game series get underway. Inter Miami will have home field advantage for their first-round clash with Nashville SC on Oct 24.

The hosts finished the regular season in third in the Eastern Conference, and they were dominant winners against their opponents this weekend on the final day of the season.

Meanwhile, Nashville have failed to win in their last two MLS matches since winning the U.S. Open Cup Final at the start of October.

Inter Miami vs. Nashville SC Overview Watch On: Apple TV

DATE & TIME

Friday, October 24, 2025 @ 8:00 PM ET
Inter Miami
Chase Stadium, Miami
Nashville SC
GAME ODDS
BetOnline
Inter Miami -208
The Draw +415
Nashville SC +451

Pressure on Inter Miami

All of the pressure this weekend will be on Inter Miami, as the franchise are the clear favorites to win the MLS Cup in 2025.

Led by Lionel Messi, Inter have won their last three matches in the MLS. Their excellent form in front of goal has seen them net an impressive 13 goals. Five of those efforts came in a 5-2 success against Nashville last Saturday.

Messi scored a hat-trick in that win, and the Argentine will be crucial to the team's chances once again this weekend.

Possible Lineup
(4-2-3-1) Novo (GK); Weigandt, Lujan, Falcon, Alba; De Paul, Busquets; Allende, Messi, Rodriguez; Suarez

Nashville Have Questions to Answer

Nashville will have big questions to answer this weekend, after narrowly avoiding dropping out of the automatic playoff spots on the final day of the season.

The team have failed to win in their last two matches since winning the U.S. Open Cup, which includes a heavy loss at the hands of Inter Miami last Saturday.

Nashville have been poor on the road throughout the season, winning just 29% of their games, and conceding an average of 1.65 goals per game.

Possible Lineup
(4-3-3) Willis (GK); Najar, Maher, Zimmerman, Lovitz; Tagseth, Yazbek, Muyi; Mukhtar, Surridge, Shaffelburg
Inter Miami vs. Nashville SC Head-to-Head Record
TOTAL Inter Miami Nashville SC DRAWS
Games 16 7 4 5
Goals 46 24 22

Inter Miami vs. Nashville SC Picks

Based on the evidence provided by the clash between these sides last weekend, it is hard to overlook a home win when making Inter Miami vs. Nashville SC picks.

Messi's form has been electric throughout the campaign. Therefore, he will be a standout selection to score on Saturday. Furthermore, Inter have won their last five head-to-head meetings with Nashville.

Pick
Inter Miami (-208)
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