Chicago Fire vs. Orlando City MLS Picks: Eastern Conference Wild-Card Round Set (Oct 22)

Published Oct 20, 5:07am ET by

Alex Dudley - Betting Preview Analyst and Sports Writer

Last updated Oct 20, 5:07am ET

Pick status
The Eastern Conference wild-card round is set for Oct 22. Find the MLS odds and our Chicago Fire vs. Orlando City picks here.

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Updated Oct 20, 5:07am ET

  • Chicago Fire finished eighth in the Eastern Conference standings, with Orlando City claiming ninth
  • A clash with the Philadelphia Union awaits the winner on Wednesday

The intense action in the MLS playoffs gets underway on Wednesday, as the wild-card clashes for the Eastern and Western conferences are set. Find our Chicago Fire vs. Orlando City picks here.

The Fire finished a place higher than their rivals in the Eastern Conference standings, and they concluded the campaign just a point off the top eight. However, the Fire have played out 2-2 draws in each of their last two games.

Orlando City failed to break into the top eight on the final day of the season after suffering a devastating 4-2 loss against Toronto.

Chicago Fire vs. Orlando City Overview Watch On: Apple TV

DATE & TIME

Wednesday, October 22, 2025 @ 8:30 PM ET
Chicago Fire
SeatGeek Stadium, Chicago
Orlando City
GAME ODDS
BetOnline
Chicago Fire +102
The Draw +286
Orlando City +238

Fire Have Home-Field Advantage

All of the pressure will be on the Chicago Fire on Wednesday, as they will have the home-field advantage in their wild-card showdown.

However, they will need a better performance than they managed last weekend, as they could only play out a 2-2 draw against New England.

Home advantage hasn't been a key trend for the Fire this term, as they have won just 35% of their home fixtures. Meanwhile, they have conceded an average of 1.47 goals per game, scoring the exact same per fixture.

Possible Lineup
(3-4-3) Brady (GK); Rogers, Waterman, Elliott; Dean, Kouame, D'Avilla, Gutman; Zinckernagel, Cuypers, Bamba

Orlando Aiming to Respond

It was an incredibly damaging end to the campaign for Orlando City, and there will almost certainly be a sense of what could have been.

A defeat on the final day of the campaign against Toronto saw them end the campaign in ninth. However, a victory in Canada would have secured eighth spot in the Eastern Conference.

Orlando City have won 35% of their away games in the MLS in 2025, and they have scored a respectable 1.59 goals per game.

Possible Lineup
(4-4-2) Gallese (GK); Marin, Schlegel, Brekalo, Freeman; Pasalic, Atuesta, Smith, Angulo; McGuire, Ojeda
Chicago Fire vs. Orlando City Head-to-Head Record
TOTAL Chicago Orlando DRAWS
Games 27 9 8 10
Goals 81 45 36

Chicago Fire vs. Orlando City Picks

A high-stakes affair is set for the Windy City on Wednesday, as the loser will exit the playoffs.

Chicago's home form has been indifferent throughout the campaign. Therefore, a chance could be taken on the free-scoring visitors when making Chicago Fire vs. Orlando City picks this week.

Pick
Orlando City (+238)
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