Red Wings vs. Sabres NHL Picks: Visitors Bidding to Continue Red-Hot Start (Oct 22)

Published Oct 21, 3:43am ET by

Alex Dudley - Betting Preview Analyst and Sports Writer

Last updated Oct 21, 3:43am ET

Pick status
The in-form Detroit Red Wings bid to register a sixth straight win on Oct 22. Find our Red Wings vs. Sabres picks here.

Credit: Shutterstock

Updated Oct 21, 3:43am ET

  • Buffalo Sabres chasing a response following a defeat on Monday
  • Detroit Red Wings currently sit top of the Atlantic Division

One of the standout teams in theΒ NHLΒ so far this season will be back in action on Oct 22, as the Red Wings travel to the Buffalo Sabres.

Detroit have made a red-hot start to the new season, winning each of their last five games to seize control at the summit of the Atlantic Division.

Meanwhile, the Buffalo Sabres will be aiming to get back on track after their winning run was ended on Monday evening. Find our picks for the clash here.

Buffalo Sabres vs. Detroit Red Wings Overview Watch On: ESPN+

DATE & TIME

Wednesday, October 22, 2025 @ 7:30 PM ET
Buffalo Sabres
KeyBank Center, Buffalo
Detroit Red Wings
GAME ODDS
BetOnline
Buffalo Sabres TBA
Detroit Red Wings TBA

Sabres Bidding for Response

The Buffalo Sabres have enjoyed a respectable start to the new campaign, but they sit sixth in the Atlantic Division after going 2-4-0.

Despite enjoying a recent winning run, they come into this clash aiming to respond following a loss on Monday against the Montreal Canadiens.

The Canadiens powered to victory after scoring three times in the final period. Buffalo's goals in the defeat were scored by Jiri Kulich and Tyson Kozak.

Red Wings Aiming to Extend Advantage

It has been a sensational start to the new season for the Detroit Red Wings, and they currently sit top of the Atlantic Division after winning their last five games.

Meanwhile, the Red Wings currently boast the best defensive record in the division. Their winning sequence continued over the weekend after beating the Edmonton Oilers 4-2.

Dylan Larkin and Emmitt Finnie netting two goals apiece in the victory.

Red Wings vs. Sabres Head-to-Head Record
TOTAL Red Wings Sabres DRAWS
WINS 166 78 75 -
GOALS 1100 546 554

Red Wings vs. Sabres NHL Picks

There have been few more eye-catching defensive teams in the NHL to this point than the Red Wings.

Therefore, they look more than capable of enhancing their winning sequence on the road when they travel to Buffalo on Wednesday. Due to this, we like the chances of a Detroit win when making Red Wings vs. Sabres picks.

Pick
Detroit Red Wings
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