Cardinals vs Rams NFL Pick: NFC West Rivalry Clash in Week 18 (Jan 4)

Published Jan 2, 6:47pm ET by

Keith McCarthy - Betting Preview Analyst and Sports Writer

Last updated Jan 2, 6:47pm ET

Pick status
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Updated Jan 2, 6:48pm ET

  • The Cardinals were pummeled by the Bengals last week, losing by a score of 37-14.
  • Los Angeles came up short on Monday night, losing 27-24 to the Falcons on the road.
  • These two teams last faced off back in Week 14, in a game that the Rams won 45-17.

The Cardinals and Rams meet this week in an NFC West faceoff. Los Angeles is locked into an NFC Wild Card spot, while Arizona is eliminated from playoff contention and focused on the NFL Draft.

Los Angeles Rams vs. Arizona Cardinals Overview Watch On: FOX

DATE & TIME

SUNDAY, JANUARY 4, 2026 @ 4:25 PM ET
Los Angeles Rams
SOFI STADIUM
INGLEWOOD, CA
Arizona Cardinals
GAME ODDS
BetOnline
Los Angeles Rams +7.5 (-105)
Arizona Cardinals -7.5 (-105)

Cardinals Focused on Draft Position

The Cardinals dropped to 3-13 following Sunday's loss in Cincinnati. They currently hold the projected 5th overall pick in the NFL Draft. Their position is the lowest of the four 3-13 teams thanks to a punishing schedule in the NFC West. Arizona has lost 8 games in a row and is likely to post a ninth this week. They'll be focused on making improvements to the defense during the draft and NFL offseason, but also have questions at QB.

Rams Locked into NFC Wild Card

The Rams were unable to stay in contention for the NFC West title last week, being locked into a Wild Card spot as either the 5 or 6 seed. There's a big benefit to landing at #5, drawing a matchup against an NFC South champion that is hovering around .500. On the other hand, landing #6 could earn them a road trip to the defending champion Eagles or the upstart Bears. They'll focus on offensive efficiency once again this week.

Cardinals vs Rams NFL Pick

The Rams won the first matchup between these two teams by 28 points, despite both teams still having something to play for at that point. Now, with the Rams seeking an ideal playoff matchup and the Cardinals focused more on draft position, the result could be even more lopsided. The rematch will also be played in Los Angeles, favoring the Rams. Take them to win this one and cover in what should be a double-digit win.

Pick
Los Angeles Rams -7.5
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