Bills vs Broncos NFL Pick: Super Bowl Hopefuls Clash in Divisional Round (Jan 16)

Published Jan 12, 11:20pm ET by

Keith McCarthy - Betting Preview Analyst and Sports Writer

Last updated Jan 12, 11:20pm ET

Pick status
Josh Allen

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Updated Jan 12, 11:20pm ET

  • The Bills took down the Jaguars on the road in a thrilling clash, defeating them 27-24.
  • Denver enjoyed their first-round bye last week as the AFC's top seed with a 14-3 record.
  • These two teams last met in last year's Wild Card round, in a game that the Bills won 31-7.

The Bills and Broncos meet this week in a key AFC clash. A trip to the AFC Championship Game awaits the winner. Buffalo is favored as the 6-seed on the road, looking to repeat last year's result.

Denver Broncos vs. Buffalo Bills Overview Watch On: CBS

DATE & TIME

SATURDAY, JANUARY 17, 2026 @ 4:30 PM ET
Denver Broncos
EMPOWER FIELD
DENVER, CO
Buffalo Bills
GAME ODDS
BetOnline
Denver Broncos +1.5 (-105)
Buffalo Bills -1.5 (-105)

Bills Seeking Return to AFC Championship

The Bills held off the Jaguars in a closely-contested Wild Card game, winning by a field goal. They'll stay on the road for the remainder of the postseason as the lowest seed remaining, though Buffalo has more playoff experience in their current unit than many of the other teams. The Bills will face Denver's excellent defense this week, needing QB Josh Allen and RB James Cook to both continue thriving to have a chance of winning.

Broncos Lean on Homefield Advantage

The Broncos had the week off to rest and prepare for this game against Buffalo. They'll be seeking revenge after being eliminated by the Bills in last season's postseason. QB Bo Nix has improved considerably since then and will be seeking an improved result. While Nix leads the way on a consistent offense, Denver's real asset is their defense, which has been comparably strong to their squad from their last title a decade ago.

Bills vs Broncos NFL Pick

Josh Allen has only ever lost in the postseason to Patrick Mahomes and Joe Burrow. Against a QB in the tier below like Bo Nix, Allen should be able to lead his team to victory should the game be close coming down to the wire. On the other hand, Denver's defense, well-rested squad, and home-field advantage could easily get the best of Buffalo. I see the Broncos entering the last quarter of the game up by enough to hold Allen off.

Pick
Denver Broncos +1.5
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