nfl NFL

Titans vs Colts NFL Pick: Cam Ward and Titans Face Uphill Battle (Oct 26)

Published Oct 24, 6:37pm ET by

Keith McCarthy - Betting Preview Analyst and Sports Writer

Last updated Oct 24, 6:37pm ET

Pick status

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Updated Oct 24, 6:38pm ET

  • The Titans lost badly yet again on Sunday, falling 31-13 to the Patriots at home.
  • Indianapolis continued to dominate on offense, defeating the Chargers 38-24.
  • These two teams last met back in Week 3, in a game that the Colts won 41-20.

The Titans and Colts face off in a divisional clash this week. Tennessee is struggling with a 1-6 record and faces a brutal task to take on the 6-1 Colts in Indianapolis. They are heavy underdogs.

Indianapolis Colts vs. Tennessee Titans Overview Watch On: CBS

DATE & TIME

SUNDAY, OCTOBER 26, 2025 @ 4:25 PM ET
Indianapolis Colts
LUCAS OIL STADIUM
INDIANAPOLIS, IN
Tennessee Titans
GAME ODDS
BetOnline
Indianapolis Colts -14.5 (-110)
Tennessee Titans +14.5 (-105)

Titans Continue to Struggle

The Titans got off to a strong start against the Patriots on Sunday, before utterly collapsing as the game progressed. Rookie QB Cam Ward continued to flash his potential while otherwise struggling to lead the NFL's worst offense behind the worst offensive line. Meanwhile, Tennessee has been just as unimpressive on defense. They will hope that interim head coach Mike McCoy will be able to finally turn things around.

Colts Surge to Top of AFC

The Colts continue to be the story of the NFL this season, improving to 6-1 following a blowout win of the Chargers on the road. Indianapolis has been solid on defense, ranking 11th in points allowed. However, their offense has been the real surprise, with QB Daniel Jones and RB Jonathan Taylor both having MVP-worthy seasons. The Colts lead the league with 33 points per game, on pace for a new franchise record.

Titans vs Colts NFL Pick

It's no question that the Colts are massively favored to win this game at home. They hold a 6-1 record to Tennessee's 1-6, and lead the league in points per game. Meanwhile, the Titans are dead last, averaging under 14 points per game. Large spreads in NFL games are notoriously risk, giving credit to the "Any Given Sunday" slogan, but it's difficult to imagine a scenario where the Colts don't run away with this one.

Pick
Indianapolis Colts -14.5
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