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Panthers vs Saints NFL Pick: An NFC South Clash in Week 15 (Dec 14)

Published Dec 12, 11:40pm ET by

Keith McCarthy - Betting Preview Analyst and Sports Writer

Last updated Dec 12, 11:40pm ET

Pick status
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Updated Dec 12, 11:43pm ET

  • The Panthers were on their bye last week, following a competitive loss to the Rams in Week 13.
  • New Orleans pulled off a major upset against the Buccaneers, beating them 24-20 on the road.
  • These two teams last faced off a month ago back in Week 10, in a game that the Saints won 17-7.

The Panthers and Saints meet in an NFC South clash. New Orleans won the first bout and will look to improve to 3-2 in divisional play this week. Carolina is suddenly in the division's top spot.

New Orleans Saints vs. Carolina Panthers Overview Watch On: FOX

DATE & TIME

SUNDAY, DECEMBER 14, 2025 @ 4:25 PM ET
New Orleans Saints
CAESARS SUPERDOME
NEW ORLEANS, LA
Carolina Panthers
GAME ODDS
BetOnline
New Orleans Saints +2.5 (-105)
Carolina Panthers -2.5 (-105)

Panthers Eyeing Up Division Title

The Panthers watched the Buccaneers lose as they enjoyed their bye week and then once again on Thursday night, allowing them to rise into 1st place in the NFC South. Despite their -50 point differential, Carolina's strong defensive play as of late has put them in a position where they now control their own destiny. The next test is a winnable game in New Orleans, though the Panthers lost their first matchup.

Saints Headed Towards Top-5 Pick

The Saints managed to earn their second win in the past four weeks against the Buccaneers, but were also mathematically eliminated from postseason contention. They currently sit 5th in the projected 2026 NFL Draft order. As New Orleans continues to play better football down the stretch, they are also at risk of jeopardizing that position. Tyler Shough will continue to stake his own claim to stay as the QB this week.

Panthers vs Saints NFL Pick

New Orleans got the better of the Panthers in their first matchup back in Week 10. However, the results of that matchup are unlikely to have an impact on the rematch. Both teams have been playing better lately, with Carolina suddenly in 1st place in the division. With Bryce Young finally showing some improvement, the Panthers should be able to take down a Saints team that has much less to play for in this game.

Pick
Carolina Panthers -2.5
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