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Packers vs Cardinals NFL Pick: Arizona Seeking to Snap Losing Streak (Oct 19)

Published Oct 15, 7:10pm ET by

Keith McCarthy - Betting Preview Analyst and Sports Writer

Last updated Oct 15, 7:10pm ET

Pick status
Jordan Love

Shutterstock

Updated Oct 15, 7:14pm ET

  • The Packers improved to 3-1-1 following their 27-18 win over the struggling Bengals.
  • Arizona came up short against the Colts, losing 31-27 for their fourth loss in a row.
  • These two teams last met on October 13, 2024, in a game that the Packers won 34-13.

The Packers and Cardinals face off this week in an NFC clash. Arizona has lost four games in a row and desperately needs a win at home here. They face an uphill battle against the Packers.

Arizona Cardinals vs. Green Bay Packers Overview Watch On: FOX

DATE & TIME

SUNDAY, OCTOBER 19, 2025 @ 4:25 PM ET
Arizona Cardinals
STATE FARM STADIUM
GLENDALE, AZ
Green Bay Packers
GAME ODDS
BetOnline
Arizona Cardinals +6.5 (-105)
Green Bay Packers -6.5 (-105)

Packers Eyeing Up Another Victory

The Packers continued to play well on Sunday, easily dispatching the struggling Bengals. Their defense didn't face much of a challenge with Joe Burrow out, but they continue to be one of the most consistent units in the league. They'll aim to keep that going in this week's game against the Cardinals. On offense, Green Bay has benefited from the stellar play of QB Jordan Love, despite a lack of healthy targets for him.

Cardinals Aim to Stop the Bleeding

The Cardinals have now lost four in a row, having fallen in a spirted effort against the Colts on Sunday. It's a disappointing result following their 2-0 start, and one that has them barely treading water in a brutal NFC West division. Arizona ranks 18th on offense and 15th on defense, yet sits 25th in the overall league standings. 3rd-year head coach Jonathan Gannon is starting to feel his seat heat up as he drops to 14-26.

Injury / Suspension
PLAYER STATUS
RB James Conner - Arizona Cardinals INJURED
WR Christian Watson - Green Bay Packers INJURED
WR Jayden Reed - Green Bay Packers INJURED

Packers vs Cardinals NFL Pick

The Cardinals may hold a moderate advantage on their own home field in this game, but they face an uphill battle nonetheless. Green Bay is the more complete team and has been playing much better football lately. With Arizona struggling to close games out, expect the Packers to take the lead and hold it for most of the game. I wouldn't expect a blowout, but Green Bay should be able to win here and cover.

Pick
Green Bay Packers -6.5
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