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Colts vs Chargers NFL Pick: A Battle Between Rising Teams (Oct 19)

Published Oct 15, 6:55pm ET by

Keith McCarthy - Betting Preview Analyst and Sports Writer

Last updated Oct 15, 6:55pm ET

Pick status
Chiefs will play the Chargers on Sept 29.

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Updated Oct 15, 6:56pm ET

  • The Colts won a thriller against the Cardinals, defeating them 31-27 to improve to 5-1.
  • Los Angeles took down the Dolphins in Miami, climbing to 4-2 following the 29-17 win.
  • These two teams last met on December 26, 2022, in a game that the Chargers won 20-3.

The Colts and Chargers meet this week in what is shaping up to be an excellent game. With a combined 9-3 record, these squads are leading the way in the AFC. The winner will rise further.

Los Angeles Chargers vs. Indianapolis Colts Overview Watch On: CBS

DATE & TIME

SUNDAY, OCTOBER 19, 2025 @ 4:05 PM ET
Los Angeles Chargers
SOFI STADIUM
INGLEWOOD, CA
Indianapolis Colts
GAME ODDS
BetOnline
Los Angeles Chargers -1.5 (-105)
Indianapolis Colts +1.5 (-105)

Colts Continue to Dominate

The Colts improved to 5-1 in their win on Sunday, defeating the Cardinals in a shootout. While it wasn't their best defensive performance, Indianapolis continues to dominate the opposition on offense. QB Daniel Jones remains atop the NFL in QBR, while RB Jonathan Taylor leads the league in rushing with 603 yards through 6 games. They'll put their offensive mettle to the test this week on the road in Los Angeles.

Chargers Stay on Top of Division

The Chargers bounced back last week, earning a win in Miami. After having lost the previous two games to the Giants and Commanders, it was a much needed victory for Los Angeles. Despite returning to the win column and sitting atop the competitive AFC West, the Chargers have some holes to fix. A growing list of injuries has made their early-season success deteriorate. They'll face a tough challenge this week.

Injury / Suspension
PLAYER STATUS
RB Omarion Hampton - Los Angeles Chargers INJURED
RB Najee Harris - Los Angeles Chargers INJURED
OT Rashawn Slater - Los Angeles Chargers INJURED
LB Khalil Mack - Los Angeles Chargers INJURED

Colts vs Chargers NFL Pick

With a combined record of 9-3, both of these teams are on pace to make the postseason. That being said, the Chargers have not looked as dominant over the last three weeks, even in their most recent win over Miami. With a struggling defense and a banged-up run game, head coach Jim Harbaugh is unlikely to be able to put together his ideal game plan. Even at home, LA is at a disadvantage against the Colts offense.

Pick
Indianapolis Colts +1.5
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