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Updated Oct 9, 2:44pm ET
- The Kansas City Chiefs dropped to 2-3 following a 31-28 loss to the Jacksonville Jaguars.
- The Detroit Lions improved to 4-1 after a double-digit win against the Cincinnati Bengals.
- These squads previously faced off on Sep. 27, 2023, with the Chiefs winning that game by a narrow 21-20 margin.
One of the games on Sunday's NFL slate features the Kansas City Chiefs hosting the Detroit Lions. Who has the edge in our Chiefs vs Lions pick?
DATE & TIME
Kansas City, MO
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Kansas City Chiefs | -1.5 (-120) |
Detroit Lions | +1.5 (-105) |
Chiefs Coming Off Disappointing Loss Against Jacksonville
Kansas City saw its two-game win streak snapped, courtesy of a 31-28 loss to the Jaguars in Week 5.
FINAL | The Chiefs allowed a late touchdown en route to a 31-28 loss Monday against the Jacksonville Jaguars.https://t.co/tbWLpzoeEG
— KSHB 41 News (@KSHB41) October 7, 2025
The Chiefs led 28-24 late in the fourth quarter. However, Jacksonville took the lead for good when Trevor Lawrence scored on a one-yard run despite falling to the ground initially.
Kansas City did get the ball back with 16 seconds left to play, but failed to reach field goal range, allowing the home team to secure a three-point victory.
Patrick Mahomes completed 29 of 41 passes for 318 yards, with one touchdown and one interception. He was also the team's leading rusher, accumulating 60 yards on six carries.
Detroit Aiming For Fifth Straight Win
After a 27-13 loss in the season opener against Green Bay, the Lions have reeled off four straight wins. This includes a 37-24 victory against the Cincinnati Bengals last week.
RECAP: Bengals fall 37-24 to Lionshttps://t.co/kiHlbZooa6
— Cincy Jungle (@CincyJungle) October 5, 2025
Detroit held a 28-3 advantage through the first three quarters. And although the Bengals put up 21 points in the final frame, it wasn't enough to prevent the Lions from winning their fourth straight. Additionally, the win snapped a seven-game losing streak against Cincinnati.
Jared Goff finished 19 of 23 for 258 yards and three touchdowns. Amon-Ra St. Brown had eight grabs for 100 yards.
Chiefs vs Lions NFL pick
Despite coming up short against the Jaguars, Kansas City enters this contest as a 1.5-point favorite. Here's a look at what you need to know for both teams ahead of this Week 6 matchup.
- The Chiefs are 14-6 straight-up (SU) in their last 20 games.
- Kansas City is 6-13 ATS in its previous 19 outings.
- The Lions are 17-3 in their last 20 contests.
- Detroit is 3-6 ATS in its previous nine matchups against the Chiefs.
In addition to their four-game win streak, the Lions have also won three of the previous five games in this series. With that in mind, look for the Lions to get the win in what should be a competitive game.
Pick
Detroit Lions
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