Chiefs vs Lions NFL Pick: Will Detroit Extend Its Win Streak To Five Games? Oct 12

Published Oct 9, 2:44pm ET by

James Tillman - Betting Preview Analyst and Sports Writer

Last updated Oct 9, 2:44pm ET

Pick status
The Chiefs look to improve to 4-2 when they host the Lions on Sunday night.

Shutterstock

Updated Oct 9, 2:44pm ET

  • The Kansas City Chiefs dropped to 2-3 following a 31-28 loss to the Jacksonville Jaguars.
  • The Detroit Lions improved to 4-1 after a double-digit win against the Cincinnati Bengals.
  • These squads previously faced off on Sep. 27, 2023, with the Chiefs winning that game by a narrow 21-20 margin.

One of the games on Sunday's NFL slate features the Kansas City Chiefs hosting the Detroit Lions. Who has the edge in our Chiefs vs Lions pick?

Kansas City Chiefs vs. Detroit Lions Overview Watch On: ESPN

DATE & TIME

SUNDAY, OCTOBER 12, 2025 @ 8:20 PM ET
Kansas City Chiefs
Arrowhead Stadium
Kansas City, MO
Detroit Lions
GAME ODDS
BetOnline
Kansas City Chiefs -1.5 (-120)
Detroit Lions +1.5 (-105)

Chiefs Coming Off Disappointing Loss Against Jacksonville

Kansas City saw its two-game win streak snapped, courtesy of a 31-28 loss to the Jaguars in Week 5.

The Chiefs led 28-24 late in the fourth quarter. However, Jacksonville took the lead for good when Trevor Lawrence scored on a one-yard run despite falling to the ground initially.

Kansas City did get the ball back with 16 seconds left to play, but failed to reach field goal range, allowing the home team to secure a three-point victory.

Patrick Mahomes completed 29 of 41 passes for 318 yards, with one touchdown and one interception. He was also the team's leading rusher, accumulating 60 yards on six carries.

Detroit Aiming For Fifth Straight Win

After a 27-13 loss in the season opener against Green Bay, the Lions have reeled off four straight wins. This includes a 37-24 victory against the Cincinnati Bengals last week.

Detroit held a 28-3 advantage through the first three quarters. And although the Bengals put up 21 points in the final frame, it wasn't enough to prevent the Lions from winning their fourth straight. Additionally, the win snapped a seven-game losing streak against Cincinnati.

Jared Goff finished 19 of 23 for 258 yards and three touchdowns. Amon-Ra St. Brown had eight grabs for 100 yards.

Chiefs vs Lions NFL pick

Despite coming up short against the Jaguars, Kansas City enters this contest as a 1.5-point favorite. Here's a look at what you need to know for both teams ahead of this Week 6 matchup.

  • The Chiefs are 14-6 straight-up (SU) in their last 20 games.
  • Kansas City is 6-13 ATS in its previous 19 outings.
  • The Lions are 17-3 in their last 20 contests.
  • Detroit is 3-6 ATS in its previous nine matchups against the Chiefs.

In addition to their four-game win streak, the Lions have also won three of the previous five games in this series. With that in mind, look for the Lions to get the win in what should be a competitive game.

Pick
Detroit Lions
New Player Bonus
50% up to $1000
Further Reading
Austin FC vs. LAFC MLS Picks: Visitors Chasing Eighth Straight Win (Oct 12)
โšฝ
Austin FC vs. LAFC MLS Picks: Visitors Chasing Eighth Straight Win (Oct 12)
LAFC have recorded victories in their last seven matches in the MLS Austin FC aiming to secure their spot in the top seven of...
Sabres vs. Bruins NHL Picks: Hosts to Maintain Reliable Start? (Oct 11)
๐Ÿ’
Sabres vs. Bruins NHL Picks: Hosts to Maintain Reliable Start? (Oct 11)
Boston Bruins recorded a 3-1 win on the opening night of the season Buffalo Sabres lost three of their last four pre-season games A...
Kings vs. Jets NHL Picks: Visitors Chasing Successive Wins (Oct 11)
๐Ÿ’
Kings vs. Jets NHL Picks: Visitors Chasing Successive Wins (Oct 11)
LA Kings chasing a second straight win to start the new season Winnipeg Jets have won 54.2% of their home games against the Kings...
Knicks vs Timberwolves NBA Pick: Will New Improve To 3-0 In Preseason Play? Oct 9
๐Ÿ€
Knicks vs Timberwolves NBA Pick: Will New Improve To 3-0 In Preseason Play? Oct 9
The New York Knicks improved to 2-0 following a 113-104 win over the Philadelphia 76ers. The Timberwolves fell to .500 (1-1) after a 135-134...