Published Oct 31, 9:36pm ET by
Keith McCarthy - Betting Preview Analyst and Sports Writer
Last updated Oct 31, 9:36pm ET
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Updated Oct 31, 9:39pm ET
The Chiefs and Bills face off this week in a classic rivalry between Patrick Mahomes and Josh Allen. Buffalo faces a tough task against the surging Chiefs, even with home-field advantage.
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| Buffalo Bills | +2.5 (-105) |
| Kansas City Chiefs | -2.5 (-105) |
The Chiefs continued to dominate on both sides of the ball last week, having no issue dispatching the Commanders. The return of WR Rashee Rice has helped rejuvenated the offense, while the defense also returned to form. Kansas City faces a much tougher task this week in Buffalo, but got the best of the Bills in their last matchup during the postseason. Keep an eye on Patrick Mahomes to do what he does best.
Mahomes doing what he does best
— NFL (@NFL) October 28, 2025
WASvsKC on ESPN/ABC
Stream on @NFLPlus and ESPN App pic.twitter.com/RvaAMOYkPV
The Bills got a much-needed bounce back win against the Panthers last week. Doing so helped them keep in striking range of the Patriots, who took over the AFC East division lead a few weeks ago. Buffalo will hope to recreate their dominant defensive performance from last week in a revenge game against the Chiefs. It'll ultimately come down to Josh Allen, James Cook, and the offense to keep up the pace.
JAMES COOK 64-YARD TD!
— NFL (@NFL) October 26, 2025
BUFvsCAR on FOX/FOX Onehttps://t.co/HkKw7uXVnt pic.twitter.com/P1SqPU9cMv
| PLAYER | STATUS |
|---|---|
| RB Isiah Pacheco - Kansas City Chiefs | INJURED |
The Chiefs and Bills rivalry has become one of the best rivalries in the NFL and this rendition is certain to be another thriller. It's hard to blame Vegas for giving the Bills some points here with how truly dominant the Chiefs have looked lately. That being said, Buffalo has won their last three regular season matchups against Kansas City, and is very tough to beat at home. Take the Bills to get the win in this one at home.
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Pick
Buffalo Bills +2.5
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