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Chargers vs Cowboys NFL Pick: Dallas Fighting for Survival (Dec 21)

Published Dec 17, 6:17pm ET by

Keith McCarthy - Betting Preview Analyst and Sports Writer

Last updated Dec 17, 6:17pm ET

Pick status
Oklahoma State will play BYU in the NCAAF on October 18

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Updated Dec 17, 6:18pm ET

  • The Chargers ended the Chiefs postseason streak on Sunday in a thrilling 16-13 victory.
  • Dallas struggled on defense once again last week, losing 34-26 to the Vikings at home.
  • These two teams last met on October 16, 2023, in a game that the Cowboys won 20-17.

The Chargers and Cowboys face off this week in a game with playoff implications. Los Angeles is on the cusp of clinching a spot, while the Cowboys find themselves inches away from elimination.

Dallas Cowboys vs. Los Angeles Chargers Overview Watch On: FOX

DATE & TIME

SUNDAY, DECEMBER 21, 2025 @ 1:00 PM ET
Dallas Cowboys
AT&T STADIUM
ARLINGTON, TX
Los Angeles Chargers
GAME ODDS
BetOnline
Dallas Cowboys -2.5 (-105)
Los Angeles Chargers +2.5 (-105)

Chargers Look to Lock Down Playoff Spot

The Chargers eliminated Patrick Mahomes and the Chiefs on Sunday, fully opening up the AFC playoff picture. Still trailing the Broncos in the division, the 10-4 Chargers have much to play for this week. RB Omarion Hampton has made a positive impact in the two weeks since returning and will have a chance to produce a massive game against the Cowboys vulnerable defense. Los Angeles is a surprise underdog.

Cowboys on Cusp of Elimination

Dallas lost once again on Sunday, dropping to 6-7-1 on the season. With a playoff chance now below 10%, the Cowboys may begin shifting the focus to the offseason. The Micah Parsons trade has been as much of a complete disaster for them as everyone expected. Expect Dallas to work on their defense extensively over the offseason. For now, they'll look to stop the bleeding at home by beating the Chargers this week.

Chargers vs Cowboys NFL Pick

The Chargers and Cowboys clash in what could become a shootout on Sunday. It's a bit surprising to see Dallas favored here, despite being at home. Their defense continues to allow over 30 points each week, which will be a considerable disadvantage against a well-coached and balanced team like the Chargers. While it's unlikely to end in a total blowout, Los Angeles should win this game without too much issue.

Pick
Los Angeles Chargers +2.5
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