Published Oct 7, 6:07pm ET by
Keith McCarthy - Betting Preview Analyst and Sports Writer
Last updated Oct 7, 6:07pm ET
Updated Oct 8, 5:48pm ET
The Cardinals and Colts face off this week in an intriguing matchup. Arizona has lost three games in a row, and is hoping to turn things around this week. They'll face an uphill battle on the road against the Colts. Indianapolis has been stellar on offense this season so far, ranking 1st overall.
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| Cardinals | +6.5 |
| Colts | -6.5 |
After a promising 2-0 start to the season, the Cardinals have now lost three in a row. Their most recent loss was a major disaster. They blew a 2-score lead in the 4th quarter at home against the winless Titans. Arizona is stuck in a very competitive NFC West division, desperately needing a win to stop the bleeding. They'll be hoping the connection between Kyler Murray and Marvin Harrison Jr. continues to grow weekly.
MARVIN HARRISON JR. ARE YOU SERIOUS?
— NFL (@NFL) October 5, 2025
TENvsAZ on CBS/Paramount+https://t.co/HkKw7uXVnt pic.twitter.com/44RgpWWK5x
The Colts bounced back with another triumphant win on Sunday, blowing out the Raiders by 34 points. Their offense continues to rank 1st in league, averaging over 32 points per game. Leading the way has been QB Daniel Jones, who is 1st in the NFL in QBR. His breakout has also benefited RB Jonathan Taylor and WR Michael Pittman Jr. Indianapolis is seeking to maintain their momentum against the Cardinals.
Jonathan Taylor runs it in for his 2nd TD of the day!
— NFL (@NFL) October 5, 2025
LVvsIND on FOX/FOX Onehttps://t.co/HkKw7uXVnt pic.twitter.com/rozsfWOdYR
The Cardinals and Colts face off in what is shaping up to be an interesting battle. The Colts certainly have the advantage on paper. They're red-hot on offense and will have the home-field advantage in this game. Arizona cannot be overlooked, but it seems likely that they'll fall to 2-4. Take the Colts to win and cover.
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Pick
Indianapolis Colts -6.5
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