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Buccaneers vs Saints NFL Pick: NFC South Rivals Clash in NOLA (Oct 26)

Published Oct 23, 12:44am ET by

Keith McCarthy - Betting Preview Analyst and Sports Writer

Last updated Oct 23, 12:44am ET

Pick status
tampa bay buccaneers

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Updated Oct 23, 12:46am ET

  • The Buccaneers had a rough result on Monday, falling 24-9 to the Lions.
  • New Orleans continued to struggle last week, losing to the Bears 26-14.
  • These two teams last met on January 5, in a game that the Bucs won 27-19.

The Buccaneers and Saints face off this week in a divisional clash. Both teams are seeking bounce back wins after losing last week. Tampa Bay is favored on the road as the division leaders.

New Orleans Saints vs. Tampa Bay Buccaneers Overview Watch On: FOX

DATE & TIME

SUNDAY, OCTOBER 26, 2025 @ 4:05 PM ET
New Orleans Saints
CAESARS SUPERDOME
NEW ORLEANS, LA
Tampa Bay Buccaneers
GAME ODDS
BetOnline
New Orleans Saints +4.5 (-105)
Tampa Bay Buccaneers -4.5 (-105)

Bucs Aim to Build on Division Lead

Tampa Bay was unable to keep their winning ways going on Monday night, losing to the Lions in their worst offensive performance of the season. The 24-9 defeat dropped the Buccaneers to 5-2 on the season. Their offense is sorely missing its key assets. With RB Bucky Irving remaining out, the Bucs rushed just 12 times for 41 yards in Detroit. Without Evans and Godwin, Mayfield completed just 28 of 50 pass attempts.

Saints Searching for Bright Spots

The Saints dropped to 1-6 on Sunday, continuing to look lost as they look for bright spots in the rebuild. WR Chris Olave was among them, who is finally healthy and has been the top target for a struggling Spencer Rattler. While his three INTs didn't help their chances, Rattler wasn't the biggest issue for New Orleans. Their rush defense was a disaster, allowing Swift and Monangai to combine for 205 rushing yards.

Injury / Suspension
PLAYER STATUS
RB Kendre Miller - New Orleans Saints INJURED
RB Bucky Irving - Tampa Bay Buccaneers INJURED
WR Mike Evans - Tampa Bay Buccaneers INJURED
WR Chris Godwin - Tampa Bay Buccaneers INJURED

Buccaneers vs Saints NFL Pick

Tampa Bay's offensive troubles due to injuries are the main reason they are favored by just 4.5 points against the 1-6 Saints. The Buccaneers may be on the road, but they'll hold a key advantage in this game, even with RB Bucky Irving remaining out. Look for the Bucs to rely less on Mayfield after throwing 50 passes in Sunday's loss, instead feeding the ball to White and Tucker. Tampa Bay should win and cover.

Pick
Tampa Bay Buccaneers -4.5
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