Published Oct 21, 7:23pm ET by
Keith McCarthy - Betting Preview Analyst and Sports Writer
Last updated Oct 21, 7:23pm ET
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Updated Oct 21, 7:26pm ET
The Bills and Panthers meet in an interesting clash this week. Buffalo is rested but coming off of a pair of losses. They'll be seeking a bounce back win against a Panthers team that is heating up.
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|---|---|
| Carolina Panthers | +7.5 (-105) |
| Buffalo Bills | -7.5 (-105) |
The Bills appeared to be running away with the AFC East after Week 5, but things have quickly changed. After losing two games they were expected to win, Buffalo now exits their bye in 2nd place in the division. They sit a half of a game back from the 5-2 Patriots, needing a win to halt their losing streak. Buffalo's offense is mostly to blame for their recent struggles. Look for Josh Allen to work his way out of his slump.
Josh Allen dumps it off to Ray Davis who dives into the end zone!
— NFL (@NFL) October 14, 2025
BUFvsATL on ESPN
Stream on @NFLPlus and ESPN App pic.twitter.com/zl0nxWAHxI
Carolina surged to 4-3 following a defensive bout with the Jets. While 3rd-year QB Bryce Young continues to rank near the bottom of the league, he has finally begun to show signs of improvement. Most notably, he holds a 10-3 TD-INT ratio since Week 11, after starting his career with a much worse 27-21 TD-INT ratio. With the defense leading the way, the Panthers will aim to pull off another upset against the flailing Bills.
Patience from Bryce Young leads to a Xavier Legette touchdown!
— NFL (@NFL) October 19, 2025
CARvsNYJ on FOX/FOX Onehttps://t.co/HkKw7uXVnt pic.twitter.com/XIiXPIXZ8m
| PLAYER | STATUS |
|---|---|
| K Tyler Bass - Buffalo Bills | INJURED |
A few weeks ago, I wouldn't have been surprised to see the Panthers getting 7.5 points at home against the Bills. Now, however, and it's a surprisingly large spread. Buffalo is certainly the better team, but they haven't won a game since September, and hold their 4 wins over teams with a combined 3-24 record. Coupled with their 24-14 loss to the Falcons, who the Panthers beat 30-0, and this is a good spread to bet.
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Pick
Carolina Panthers +7.5
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