nfl NFL

Bills vs Browns NFL Pick: Buffalo Seeks to Build on Hot Streak (Dec 21)

Published Dec 17, 6:07pm ET by

Keith McCarthy - Betting Preview Analyst and Sports Writer

Last updated Dec 17, 6:07pm ET

Pick status
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Updated Dec 17, 6:11pm ET

  • The Bills won a thriller in New England on Sunday, defeating the Patriots 35-31.
  • Cleveland was pummeled by the Bears, losing 31-3, and dropping to 3-11 overall.
  • These two teams last met on November 20, 2022, in a game that the Bills won 31-23.

The Bills and Browns meet this week in what may be a lopsided game. Buffalo is heating up down the stretch and is a 10-point favorites over the eliminated Browns, despite playing in Cleveland.

Cleveland Browns vs. Buffalo Bills Overview Watch On: CBS

DATE & TIME

SUNDAY, DECEMBER 21, 2025 @ 1:00 PM ET
Cleveland Browns
HUNTINGTON BANK FIELD,
CLEVELAND, OH
Buffalo Bills
GAME ODDS
BetOnline
Cleveland Browns +10.0 (-105)
Buffalo Bills -10.0 (-105)

Bills Heating up at Ideal Time

The Bills have now won three games in a row, fully snapping out of their cold stretch. Having toppled the Patriots in New England, Buffalo now sits just one game back in the division race, giving them a chance to maintain their streak of division titles. They first need to make quick work of winnable games like this one against the Browns. Their offensive line will need to be at their very best to contain Myles Garrett.

Myles Garrett Eyes NFL Sack Record

Myles Garrett continues to be the biggest bright spot in another lost season for the Browns. Just one sack away from tying Michael Strahan and T.J. Watt's record, Garrett continues to be the very best defender in football. Unfortunately, Cleveland's ability to capitalize on his talent and become a winning teams appears to be nonexistent. They'll aim to end the bleeding in what is certain to be an uphill battle against the Bills.

Bills vs Browns NFL Pick

The Bills enter this game as major favorites against the flailing Browns. Whether or not they can cover a 10-point spread on the road depends on how well the offensive line can contain Myles Garrett. Cleveland's defensive ability, home-field advantage, and potential to score garbage time points are all reason to bet on them covering, but this will ultimately come down to overall talent. The Bills should win it handedly.

Pick
Buffalo Bills -10.0
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