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49ers vs Giants NFL Pick: Injured Squads Searching for Wins (Nov 2)

Published Oct 28, 7:45pm ET by

Keith McCarthy - Betting Preview Analyst and Sports Writer

Last updated Oct 28, 7:45pm ET

Pick status
Cardinals will play the 49ers at the Levi's Stadium on Oct 6.

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Updated Oct 28, 7:48pm ET

  • The 49ers came up short in Houston on Sunday, losing 26-15 and dropping to 5-3.
  • New York struggled defensively once again, falling 38-20 to the Eagles in Philly.
  • These teams last met on September 21, 2023, in a game that the 49ers won 30-12.

The 49ers and Giants meet this week in a battle of banged-up teams. Both have lost several key players and are making the most of what they have. The 49ers enter as marginal road favorites.

New York Giants vs. San Francisco 49ers Overview Watch On: CBS

DATE & TIME

SUNDAY, NOVEMBER 2, 2025 @ 1:00 PM ET
New York Giants
METLIFE STADIUM
EAST RUTHERFORD, NJ
San Francisco 49ers
GAME ODDS
BetOnline
New York Giants +2.5 (-105)
San Francisco 49ers -2.5 (-105)

49ers Aim to Stay Afloat Despite Injuries

The 49ers benefited from George Kittle's return this week, after he struggled in his first game back last week. Yet, Kittle being back and McCaffrey's continued dominance in the receiving game have not been enough to fully jumpstart San Francisco's offense. With QB Brock Purdy and top WRs Ricky Pearsall and Brandon Aiyuk remaining out, they will need to bounce back defensively to aid the banged-up offense.

Giants Suffer Another Devastating Blow

The Giants have had quite the up-and-down season, with it continuing into Philly on Sunday. After their collapse last week in Denver, the Giants fell to 0-5 on the road following the loss to the Eagles. Even worse than the defeat was a devastating injury to promising rookie RB Cam Skattebo. Having already lost star WR Malik Nabers, New York is just hoping that Jaxson Dart can stay healthy as they plan for the future.

Injury / Suspension
PLAYER STATUS
QB Brock Purdy - San Francisco 49ers INJURED
WR Brandon Aiyuk - San Francisco 49ers INJURED
WR Ricky Pearsall - San Francisco 49ers INJURED
WR Malik Nabers - New York Giants INJURED
RB Cam Skattebo - New York Giants INJURED

49ers vs Giants NFL Pick

The 49ers are only favored by 2.5 points in this game, despite their 5-3 record. The distance of travel, recent struggles, and compounding injuries are all surely playing a role. On the other hand, while the Giants are 2-1 at home, they continue to lose important pieces. Expect this game to be relatively low-scoring, with the 49ers ultimately winning it by more than enough points to cover the 2.5 point spread.

Pick
San Francisco 49ers -2.5
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