Tulane vs Ole Miss NCAA Pick: CFP First-Round Showdown in Oxford (Dec 20)

Published Dec 17, 5:02pm ET by

Gabriel Kozlow - Betting Preview Analyst and Sports Writer

Last updated Dec 17, 5:02pm ET

Pick status
Oregon will play Michigan in the NCAAF on November 2
  • Tulane (11-2) beat North Texas 31-21 in their last game.
  • Ole Miss (11-1) also won their last game 38-19 against Mississippi State.
  • These teams played recently on September 20th, 2025, with Ole Miss winning 45-10.

We have a CFP First Round matchup with the Tulane Green Wave visiting the Ole Miss Rebels in Oxford, Mississippi. The all-time series between these teams is led by the Rebels, with a 43–28 overall record.

OLE MISS REBELS vs. TULANE GREEN WAVE Overview Watch On: TNT

DATE & TIME

SATURDAY, DECEMBER 20, 2025 @ 3:30 PM ET
OLE MISS REBELS
Vaught-Hemingway Stadium
Oxford, MS
TULANE GREEN WAVE
GAME ODDS
BetOnline
OLE MISS REBELS -1000
TULANE GREEN WAVE +650

Tulane Banking on Cinderella Momentum

The Tulane Green Wave will be taking part in their first-ever CFP, which makes them a long shot to go further in the playoffs. It’s an exciting time for Tulane, as they ended the season as champions of the American Conference with a win against North Texas. They come into this game as heavy underdogs, but they’re happy to be part of the playoff picture.

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Jake Retzlaff, their star QB, had a solid season, leading the team to an 11–2 record so far. He was effective through the air with 14 passing TDs, but even more impressive on the ground with 16 rushing TDs. The fact that he finished with more rushing production than his running backs says a lot about his style of play.

Rebels Look for Top Offensive Performance

Ole Miss finished the season strong at 11–1 overall, earning its first-ever home game in the CFP. This is largely thanks to a top-tier offense, ranking 3rd in passing yards per game, 10th in scoring, and 3rd in total yards per game.

On the other hand, their defense has also been solid, making them a well-balanced team to play against. They rank 20th in passing yards allowed and 24th in opponent points per game. Another factor in their favor is history: Ole Miss has beaten Tulane 43 times in the past.

Tulane vs Ole Miss NCAA Pick

Ole Miss will be happy to play at home for the first time in a playoff game. They must also be happy to be heavy favorites for this one at -17.5 on the spread. The over/under for the game is 56.5, which suggests Ole Miss will be looking to put up a big score.

Our pick is the over 56.5, as we feel this will be a high-scoring affair. We also think Ole Miss will win comfortably, but we’re not fully convinced they’ll cover the spread.

Pick
Over 56.5
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