#1 Ohio State vs #17 Illinois NCAAF Pick: A Key Face Off in the Big-10 (Oct 11)

Published Oct 8, 4:47pm ET by

Gabriel Kozlow - Betting Preview Analyst and Sports Writer

Last updated Oct 8, 4:47pm ET

Pick status
football eagles

Pixabay-Keith Johnston

  • Top-ranked Ohio State (5-0) obliterated Minnesota 42-3 this past week.
  • Illinois (5-1) is also coming off a 43-27 win from their visit to Purdue.
  • The Buckeyes have won their last 9 meetings against Illinois.

#1 Ohio State will visit #17 Illinois in one of the most anticipated ranked matchups this Saturday. Ohio State has been on a tear, ripping through offensively and defensively over every team they've faced so far. Illinois will do their best to defend their home field against their biggest test yet.

ILLINOIS FIGHTING ILLINI vs. OHIO STATE BUCKEYES Overview Watch On: FOX

DATE & TIME

SATURDAY, OCTOBER 11, 2025 @ 10:00 AM ET
ILLINOIS FIGHTING ILLINI
MEMORIAL STADIUM
CHAMPAIGN, IL
OHIO STATE BUCKEYES
GAME ODDS
BetOnline
ILLINOIS +14.5 (-105)
OHIO STATE -14.5 (-105)

Ohio State Has Been Flawless

The Buckeyes, have only permitted 25 points from their rivals in their past 5 games, making them unbeatable. They are coming off two Big Ten battles against Minnesota and Washington, and both were easy blowouts. With a spread of -14.5 against Illinois, expect another potential win.

Ohio State is led at the helm by Julian Sayin with 1,313 passing yards, 13 TDs and only 3 INTs. His favorite target, Jeremiah Smith, has received 6 TDs, nearly half of the passing touchdowns this season.

Illinois Depend on Luck and Home Crowd

Is there anything you can do against a team like Ohio State? Despite their QB, Luke Altmyer having a fantastic season, they'll need even more from him to topple the Buckeyes defense.

Illinois is coming off a Purdue and USC wins, but they'll need to drastically improve their productive as well as a little luck to get them a victory. They are ranked #17 in the nation, so the Fighting Illini are a great team, but the Buckeyes have the historic dominance, the consistency and a much deeper roster.

#1 Ohio State vs #17 Illinois NCAAF Pick

The spread is a -14.5 in favor of Ohio State, despite them being the road team. The over and under for the match is a 49.5, which implies that Ohio State might receive more than 5 points for the first time this season. The money line is a -750 for Ohio State and +475 for Illinois at home.

We can't choose any other pick than Ohio State beating the spread. If you are unsure, they will cover, a money line can keep you calm while enjoying the game.

Pick
Ohio State -14.5
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