#2 Indiana vs #1 Ohio State NCAAF Pick: Top Two Clash in B1G Title Game (Dec 6)

Published Dec 4, 10:05pm ET by

Keith McCarthy - Betting Preview Analyst and Sports Writer

Last updated Dec 4, 10:05pm ET

Pick status
UCF will play Iowa State in the NCAAF on October 19

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Updated Dec 4, 10:21pm ET

  • Indiana dominated Purdue last week, winning 56-3 to earn a team-record 12th win.
  • Ohio State took down Michigan on the road, defeating them 27-9 to improve to 12-0.
  • These two teams last met on November, 23, 2024, in a game that Ohio State won 38-15.

The Big-10 Championship Game takes place this week between the top two teams in the country. Both are locks for the CFP. The winner will earn the #1 spot as the nation's final undefeated team.

Ohio State Buckeyes vs. Indiana Hoosiers Overview Watch On: FOX

DATE & TIME

SATURDAY, DECEMBER 6, 2025 @ 8:00 PM ET
Ohio State Buckeyes
LUCAS OIL STADIUM
INDIANAPOLIS, IN
Indiana Hoosiers
GAME ODDS
BetOnline
Ohio State Buckeyes -4.0 (-105)
Indiana Hoosiers +4.0 (-105)

Indiana Continues Historic Run

Indiana improved to 12-0 last week, setting a new program record in wins. They eclipsed last season's 11-win total, which had also set a record at the time. Now 23-2 in the Curt Cignetti era, the Hoosiers prepare for their toughest challenge yet, the 12-0 Buckeyes. A win would be absolutely historic for an Indiana team that hasn't beaten Ohio State since 1988. QB Fernando Mendoza faces the ultimate test this week.

Ohio State Seeking Another Title

Ohio State is seeking back-to-back college football championships. After spending most of the season undefeated and ranked #1, they'll face the only other unbeaten team. The Buckeyes beat an equally strong Hoosiers team last year by 23 points, but this year should provide a much closer result. Without home-field advantage, Ohio State will turn to their suffocating defense to make things tough for Indiana.

#2 Indiana vs #1 Ohio State NCAAF Pick

Everyone tuning into this game will be wondering if Indiana can pull off the impossible and claim the #1 spot in the College Football Playoff. They hold a slightly better point differential at +401 than the Buckeyes at +351. This game should come down to the wire, which makes a field goal margin quite realistic. Taking Indiana to cover the 4-point spread is the safest bet in what should be a thrilling game.

Pick
Indiana Hoosiers +4.0
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