#21 Iowa vs #17 USC NCAAF Pick: Iowa Look to Spoil Trojans’ Playoff Push (Nov 15)

Published Nov 14, 10:56pm ET by

Gabriel Kozlow - Betting Preview Analyst and Sports Writer

Last updated Nov 14, 10:56pm ET

Pick status
football eagles

Pixabay-Keith Johnston

Updated Nov 14, 10:56pm ET

  • #21 Iowa (6-3) are coming off a tough 16-18 loss to Oregon.
  • #17 USC (7-2) beat Northwestern with a comfortable 38-17 win.
  • Their last matchup was in 2019, where Iowa won 49-24.

Iowa Hawkeyes will pay a visit to Los Angeles Memorial Coliseum to battle USC in a ranked match that's sure to catch attention. Both teams are making a playoff push, however, if USC takes the victory, they'll be in a good position to cement themselves and meet their season goals. The all-time series between each other has Iowa with the 7-3 edge.

USC TROJANS vs. IOWA HAWKEYES Overview Watch On: BTN

DATE & TIME

SATURDAY, NOVEMBER 15TH, 2025 @ 2:30 PM ET
USC TROJANS
Los Angeles Memorial Coliseum
Los Angeles, CA
IOWA HAWKEYES
GAME ODDS
BetOnline
USC TROJANS -230
IOWA HAWKEYES +195

Iowa Look to Hold USC Offense Down

The Iowa Hawkeyes are heading over to the West Coast to battle the Trojans in a Big Ten Conference matchup. Iowa is coming off a loss against a stacked Oregon team, so they will be prepared to try and slow down the Trojan's effective offense.

The Hawkeyes have had a difficult time against ranked teams this season, as they are 0-3. They'll need to be on their A game, especially in defense, as they'll need to shut down USC's Wide Receivers. So, expect the Hawkeyes to make life difficult this weekend, especially as the underdogs going into this one.

Trojans Chase Playoff Dreams at Home

USC enters this game ranked #17 in the nation and are motivated to win this game to keep their playoff dreams alive. The Trojans have been difficult to beat at home this season, especially with unranked team, as they are 18-1 in their last 19 home games against unranked teams. We know the Hawkeyes are currently ranked, but this feels like a potential beating at the Colosseum.

The Trojans will need their star QB to be on his toes. Jason Maiava, their QB, has had a great season, however, he has been a bit reckless as he has thrown at least one INT in his last 5 games. He'll be looking for his #1 target, his WR Makai Lemon, who already has 7 TDs and 937 Receiving Yards.

#21 Iowa vs #17 USC NCAAF Pick

The USC Trojans are favorites this game at home with a -6.5 spread. The over/under for the game is 48.5, so expect this game to be a relatively low scoring game. The Moneyline has the Trojans at -230 and Iowa at +195.

The onyl way the Hawkeyes can ruin the Trojan's party is by shutting down USC's wide receivers. The more pressure they put on the QB, the more they will force a turnover and mistakes. However, we will the home team will prevail, so we pick USC at -6.5 for the game.

Pick
USC -6.5
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